Hypertension, Pulmonary Clinical Trial
Official title:
A Clinical Trial of Aspirin and Simvastatin in Pulmonary Arterial Hypertension
The purpose of this study is to determine whether aspirin and simvastatin are safe and effective for the treatment of pulmonary arterial hypertension (PAH).
PAH is characterized by dyspnea, fatigue, and lower extremity edema as a result of heart
failure. In PAH, in situ thrombosis may occur in the lungs, and pulmonary endothelial
dysfunction is well-recognized. As aspirin inhibits platelet aggregation, there may be value
in using aspirin to treat PAH. Simvastatin has beneficial effects on blood vessels in other
types of cardiovascular disease. Therefore, simvastatin may similarly benefit patients with
PAH.
Participants in this study will be randomly assigned to receive 6 months of daily placebo
tablets, daily aspirin and daily placebo, daily simvastatin and daily placebo, or daily
aspirin and daily simvastatin in a double-blind fashion. The study will compare the safety
and efficacy of aspirin to placebo and simvastatin to placebo.
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