Hypertension Clinical Trial
Official title:
A Randomized, Placebo-Controlled, Double-Blind, Six-Arm, Dose Escalation, Multi-Center Study to Evaluate the Efficacy and Safety of SLV306: 150, 300, 600 mg Once Daily, 150-300 mg Twice Daily and Amlodipine 5-10 mg Once Daily in Subjects With Hypertension
This study is to compare the efficacy and safety of increasing doses of SLV306 with amlodipine.
| Status | Completed |
| Enrollment | 0 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years and older |
| Eligibility |
Inclusion Criteria: - sitting office diastolic blood pressure between 90 and 109 mmHg - office systolic blood pressure between 140 and 179 mmHg - mean day-time diastolic 24-h ABPM blood pressure >= 85 mmHg inclusive at baseline Exclusion Criteria: - known secondary hypertension - decompensated congestive heart failure |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| Australia | Site 705 | Bracken Ridge | |
| Australia | Site 706 | Caboolture | |
| Australia | Site 700 | Inala | |
| Australia | Site 701 | Kippa Ring | |
| Australia | Site 702 | Melbourne | |
| Australia | Site 703 | Nedlands | |
| Bulgaria | Site 952 | Haskovo | |
| Bulgaria | Site 955 | Pleven | |
| Bulgaria | Site 951 | Plovdiv | |
| Bulgaria | Site 956 | Plovdiv | |
| Bulgaria | Site 950 | Sofia | |
| Bulgaria | Site 953 | Sofia | |
| Bulgaria | Site 954 | Sofia | |
| Bulgaria | Site 957 | Sofia | |
| Denmark | Site 402 | Aalborg | |
| Denmark | Site 401 | Ballerup | |
| Denmark | Site 403 | Vejle | |
| Estonia | Site 850 | Tallinn | |
| Germany | Site 119 | Aschaffenburg | |
| Germany | Site 101 | Bad Nauheim | |
| Germany | Site 104 | Bad Woerishofen | |
| Germany | Site 106 | Beckum | |
| Germany | Site 110 | Deidesheim | |
| Germany | Site 107 | Karlsruhe | |
| Germany | Site 118 | Kassel | |
| Germany | Site 109 | Krombach | |
| Germany | Site 113 | Ladenburg | |
| Germany | Site 102 | Leipzig | |
| Germany | Site 112 | Lollar | |
| Germany | Site 114 | Magdeburg | |
| Germany | Site 111 | Marburg | |
| Germany | Site 105 | Muenster | |
| Germany | Site 115 | Niederstetten | |
| Germany | Site 120 | Rodgau Dudenhofen | |
| Germany | Site 116 | Vellmar | |
| Germany | Site 103 | Wiesbaden | |
| Germany | Site 117 | Wolmirstedt | |
| Hungary | Site 800 | Budapest | |
| Hungary | Site 805 | Budapest | |
| Hungary | Site 803 | Gyongyos | |
| Hungary | Site 801 | Kecskemet | |
| Hungary | Site 804 | Pecs | |
| Hungary | Site 802 | Szekesfehervar | |
| Israel | Site 300 | Ashkelon | |
| Israel | Site 306 | Ashkelon | |
| Israel | Site 304 | Beer Sheva | |
| Israel | Site 311 | Haifa | |
| Israel | Site 305 | Jerusalem | |
| Israel | Site 310 | Kfar Saba | |
| Israel | Site 303 | Kiryat Ata | |
| Israel | Site 308 | Petach-Tikva | |
| Israel | Site 302 | Tel-Aviv | |
| Israel | Site 301 | Tel-Hashomer | |
| Israel | Site 309 | Tiberias | |
| Latvia | Site 932 | Daugavpils | |
| Latvia | Site 930 | Kuldiga | |
| Latvia | Site 931 | Riga | |
| Latvia | Site 933 | Riga | |
| Latvia | Site 934 | Riga | |
| Latvia | Site 935 | Riga | |
| Lithuania | Site 920 | Kaunas | |
| Lithuania | Site 923 | Klaipeda | |
| Lithuania | Site 921 | Vilnius | |
| Slovakia | Site 600 | Bratislava | |
| Slovakia | Site 601 | Bratislava | |
| Slovakia | Site 607 | Kosice | |
| Slovakia | Site 608 | Kosice | |
| Slovakia | Site 602 | Levice | |
| Slovakia | Site 605 | Lucenec | |
| Slovakia | Site 603 | Nove Zamky | |
| Slovakia | Site 606 | Vrable | |
| United Kingdom | Site 262 | Addlestone | |
| United Kingdom | Site 229 | Airdrie | |
| United Kingdom | Site 234 | Alexandria | |
| United Kingdom | Site 245 | Bangor | |
| United Kingdom | Site 241 | Barrhead | |
| United Kingdom | Site 224 | Bath | |
| United Kingdom | Site 240 | Bath | |
| United Kingdom | Site 230 | Bellshill | |
| United Kingdom | Site 261 | Bexhill on sea | |
| United Kingdom | Site 243 | Bexhill- on-Sea | |
| United Kingdom | Site 255 | Blackpool | |
| United Kingdom | Site 222 | Blantyre | |
| United Kingdom | Site 232 | Calderbank | |
| United Kingdom | Site 236 | Chesterfield | |
| United Kingdom | Site 219 | Chippenham | |
| United Kingdom | Site 256 | Chippenham | |
| United Kingdom | Site 237 | Co Tyrone | |
| United Kingdom | Site 216 | Coatbridge | |
| United Kingdom | Site 238 | Cornwall | |
| United Kingdom | Site 207 | Coventry | |
| United Kingdom | Site 247 | Cumbernauld | |
| United Kingdom | Site 208 | Dumbarton | |
| United Kingdom | Site 235 | East Horsley | |
| United Kingdom | Site 220 | Ely | |
| United Kingdom | Site 257 | Frome | |
| United Kingdom | Site 210 | Glasgow | |
| United Kingdom | Site 221 | Glasgow | |
| United Kingdom | Site 227 | Glasgow | |
| United Kingdom | Site 233 | Glasgow | |
| United Kingdom | Site 251 | Glasgow | |
| United Kingdom | Site 201 | Greenisland | |
| United Kingdom | Site 252 | Helensburgh | |
| United Kingdom | Site 249 | Hook | |
| United Kingdom | Site 200 | Leamington SPA | |
| United Kingdom | Site 226 | Maidenhead | |
| United Kingdom | Site 246 | Maidenhead | |
| United Kingdom | Site 213 | Manchester | |
| United Kingdom | Site 244 | Melksham | |
| United Kingdom | Site 259 | Middlesex | |
| United Kingdom | Site 202 | Motherwell | |
| United Kingdom | Site 206 | Motherwell | |
| United Kingdom | Site 217 | Motherwell | |
| United Kingdom | Site 239 | Motherwell | |
| United Kingdom | Site 231 | Paisley | |
| United Kingdom | Site 250 | Paisley | |
| United Kingdom | Site 242 | Penzance | |
| United Kingdom | Site 218 | Plymouth | |
| United Kingdom | Site 223 | Plymouth | |
| United Kingdom | Site 254 | Reading | |
| United Kingdom | Site 212 | Riddrie | |
| United Kingdom | Site 253 | Sandy | |
| United Kingdom | Site 258 | Sheffield | |
| United Kingdom | Site 205 | Slough | |
| United Kingdom | Site 215 | St Just | |
| United Kingdom | Site 211 | Strathaven | |
| United Kingdom | Site 225 | Swansea | |
| United Kingdom | Site 209 | Thornhill | |
| United Kingdom | Site 248 | Woking | |
| United Kingdom | Site 228 | Wokingham |
| Lead Sponsor | Collaborator |
|---|---|
| Solvay Pharmaceuticals |
Australia, Bulgaria, Denmark, Estonia, Germany, Hungary, Israel, Latvia, Lithuania, Slovakia, United Kingdom,
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