Hypertension Clinical Trial
Official title:
Multicenter, Open-Label (Non-Comparative) Study To Evaluate Changes In Flow Mediated Dilatation During And After A 6 Months Treatment Period With Step By Step Increased Doses With Quinapril Therapy In Post-Menopausal Women With Mild Or Moderate Hypertension
ACE inhibitors are thought to modify the endothelium in a number of ways. Quinapril is an
effective and well-tolerated ACE-I for the treatment of patients with hypertension and
congestive heart failure. Quinapril produces favourable haemodynamic changes and improves
ventricular and endothelial function in patients with various cardiovascular disorders.
These effects are mediated through the binding of quinaprilat to both tissue and plasma-ACE.
Quinapril 10 to 40 mg once daily improved endothelial function (as measured by improved FMD
or reduced vasoconstrictive/increased vasodilative response to Ach) in patients with CAD and
hypertension over 2 to 6 months of therapy; improved endothelial function was also observed
in patients with CHF receiving a single infusion of quinaprilat. In general, quinapril
showed neutral or beneficial effects on lipid profiles, glycaemia and renal haemodynamics.
(3) There are no data available considering effects of quinapril on endothelial dysfunction
in post- menopausal woman with mild to moderate hypertension and with pathological
endothelial function.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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