Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance

Hypertension Clinical Trial

Official title:

Impact of Ambulatory Blood Pressure Monitoring for Antihypertensive Treatment Guidance in Medical Outpatients: The Hyper-ABC Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00139984
• Other study ID #: EKBB183/03
• Status: Completed
• Phase: Phase 4
• First received: August 29, 2005
• Last updated: February 1, 2017
• Start date: October 2003
• Est. completion date: May 2007

Study information

• Verified date: February 2017
• Source: University Hospital, Basel, Switzerland
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine whether in patients with arterial hypertension, treatment guidance using 24-hour blood pressure measurement results in better blood pressure control compared to treatment guidance using office blood pressure measurement.

Description:

Blood pressure control in arterial hypertension remains poor, despite the availability of effective drug treatment. Therefore, strategies to increase blood pressure control are urgently needed. 24 hour blood pressure is a better predictor of cardiovascular morbidity and mortality than office blood pressure. Furthermore, the lower variability of measurements over time of 24 hour blood pressure could allow better adjustment of antihypertensive therapy. However, there are only scarce data about antihypertensive treatment adjustment using 24 hour blood pressure instead of office blood pressure.

Aim: To test the hypothesis that a 24 hour blood pressure guided therapy is is more effective in reaching blood pressure control when compared to conventional office blood pressure guided therapy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 170
• Est. completion date: May 2007
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Uncontrolled hypertension (office BP >139/89mmHg AND 24h BP >129/79mmHg)

Exclusion Criteria:

• Severe concomitant illness including heart failure, significant valvular heart disease or malignancy

Related Conditions & MeSH terms

• Hypertension

Intervention

Device:
• 24 hour blood pressure measurement

Locations

Country	Name	City	State
Switzerland	Medical Outpatient Clinic, University Hospital Basel	Basel
Switzerland	Private Practice	Basel

Sponsors (2)

Lead Sponsor	Collaborator
University Hospital, Basel, Switzerland	Bayer

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in 24-hour systolic blood pressure from baseline to 1 year
Secondary	Change in 24-hour diastolic blood pressure from baseline to 1 year
Secondary	Primary outcome measure in patients with treated hypertension at baseline