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Hypertension clinical trials

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NCT ID: NCT03121196 Not yet recruiting - Clinical trials for Gestational Diabetes

Social Deprivation and Pregnancy

Start date: May 2017
Phase: N/A
Study type: Observational

Social deprivation during pregnancy is associated to adverse perinatal outcomes. However, prenatal screening of social deprivation by reliable measurement is not performed. Prevalence of social deprivation is yet underestimated during pregnancy and vulnerable women are not being provided optimal prenatal care. Our aim is to validate EPICES score during pregnancy.

NCT ID: NCT03102294 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

Inspiratory Muscle Training in Chronic Thromboembolic Pulmonary Hypertension

Start date: September 1, 2017
Phase: N/A
Study type: Interventional

Inspiratory muscle training for 8 weeks in patients with chronic thromboembolic pulmonary hypertension.

NCT ID: NCT03080519 Not yet recruiting - Clinical trials for Renal Artery Obstruction

Endovascular Therapy for Renal Artery Stenosis in China

ETRAS-China
Start date: April 2017
Phase: N/A
Study type: Interventional

A multicenter prospective registry planned to recruit more than 5 000 patients with renal artery stenosis was carried out in China. This primary purpose of this study was to evaluate the safety and efficacy of renal artery revascularization in the real world. The secondary purpose was to investigate the etiologic distribution of renal artery stenosis and optimize the indications for renal artery revascularization.

NCT ID: NCT03045666 Not yet recruiting - Clinical trials for Pulmonary Arterial Hypertension

Impact of Rehabilitation Program on PAH Patients Treated With Macitentan.

Start date: April 15, 2017
Phase: N/A
Study type: Interventional

48 patients, over the age of 18, with pulmonary arterial hypertension (PAH) classified as WHO III-IV, that are all stable under Macitentan therapy ( medication for treating PAH patients), will be recruited to the study through the pulmonary hypertension (PH) clinic at Soroka Medical Center. The patients will be randomly divided into an intervention group, which will exercise twice a week for 12 weeks, supervised by physiotherapists, and a control group, which will only receive the medication. Tests will be performed before the beginning of the intervention program, 6 weeks after it has begun, at the end of the 12 week program, and 3 months after finishing the program.

NCT ID: NCT03027791 Not yet recruiting - Hypertension Clinical Trials

Sodium Healthy Living Project

SoHELP
Start date: January 2017
Phase: N/A
Study type: Interventional

Subjects will participate in a 12-week church-based intervention with five separate components: 1) participation in weekly group sessions; 2) daily use of Fitbit activity tracker; 3) daily, twice a day blood pressure monitoring; 4) daily online food tracking; and 5) daily use of VR at home (starting at week 6). Participants will also receive phone contacts from nurse coaches (twice a week during the first 4 weeks, then once a week for the remaining 8 weeks), who will answer questions and provide support.

NCT ID: NCT03000842 Not yet recruiting - Hypertension Clinical Trials

Effects of Transcutaneous Vagal Nerve Stimulation on Hemodynamics Parameters

Start date: January 2017
Phase: N/A
Study type: Interventional

The vagal stimulation is a promising therapy for a lot of disorders as well as hemodynamic regulatory way. In order to minimize the harm of a surgery chip implantation, actually it was developing a non-invasive device that is able to stimulate the auricular branch of vagal nerve. It has been shown that trans-auricular vagal stimulation (tVNS) causes direct stimulation of the vagal nerve. However, there are still no strong evidences about it actions regarding the autonomic modulation. The aim of this study is to evaluate effects of tVNS on heart rate, blood pressure and the autonomic control in healthy and hypertensive subjects, at rest and after orthostatic position

NCT ID: NCT02988362 Not yet recruiting - Hypertension Clinical Trials

Bioequivalence Study (Candesartan 16 mg and Amlodipine 10 mg)

Start date: December 2016
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the safety and pharmacokinetics of HL068 (Candesartan 16 mg and Amlodipine 10mg) with coadministration of the two separate drugs in healthy male volunteers.

NCT ID: NCT02988245 Not yet recruiting - Hypertension Clinical Trials

Investigating the Use of Genetics to Guide Pharmacologic Therapy for Hypertension

PGEN for HTN
Start date: June 2022
Phase: Phase 2
Study type: Interventional

Hypertension is one of the most important preventable contributors to disease and death in the United States and represents the most common condition seen in the primary care setting. Approximately 78 million adults living in the U.S. have hypertension with more than 5 million new diagnoses made each year. Unfortunately, despite a significant impulse in the medical community to move towards an "individualized medicine" approach to patient centered treatment, the current clinical treatment strategy is based on a set algorithm which does not take into account individual patient differences. As a result hypertension is often sub-optimally treated based on "population averages", rather than a person's genetic make-up, with significant burden on our health care system. In fact, 40% of patients who are adherent to their blood pressure therapy (taking their medicines as prescribed by their clinician) do not have their blood pressure under control. Previous work has demonstrated significant functional polymorphisms within the kidney, vessels, and heart that will likely predict a patient's response to blood pressure pharmacotherapy. Previous work by our group, utilizing a retrospective design, has determined that the addition of genetic knowledge to prescribing can improve therapeutic guidance and decrease the time to blood pressure control significantly. Despite this, to date, there are no prospective trials to guide blood pressure therapy using multiple organ systems that are important in the three most common classes of drugs: diuretics, vasodilators, and beta-blockers. The objective of this clinical trial is to determine the efficacy of genetically guided therapeutic options for pharmacologic treatment of essential hypertension in newly diagnosed patients.

NCT ID: NCT02987452 Not yet recruiting - Hypertension Clinical Trials

Acute Effects of Different Exercises on Blood Pressure in Hypertensive Subjects

Start date: January 2017
Phase: N/A
Study type: Interventional

Lifestyle changes might reduce cardiovascular risk due to the decrease in blood pressure (BP). However, whether combining aerobic and resistance exercises affect BP and hemodynamic parameters, as well as arterial stiffness and inflammation markers in resistant hypertensive (RHTN) patients, have not been investigated yet.

NCT ID: NCT02928666 Not yet recruiting - Hypertension Clinical Trials

Integration of Guidelines for Comorbidities

Start date: October 2018
Phase: N/A
Study type: Interventional

Introduction: in the course of the research, the investigators will develop a decision-support system (comorbidity-DSS) consisting (1) a knowledge base (KB) consisting of (a) computer-interpretable clinical guidelines for type 2 diabetes and 2 other diseases from: obstructive pulmonary disease, osteoporosis, hypertension, and osteoarthritis; and (b) an ontology of relevant general medical knowledge that could complement (a) in order to propose non conflicting treatment options not mentioned in the clinical practice guidelines; and (2) an algorithm that matches the KB with a patient's data set to identify the guidelines-based recommendations applicable for the patient and their interactions and which proposes ways to mitigate conflicting interactions (e.g., suggesting to select intervention A.2 (instead of A.1) from guideline A and intervention B.3 (instead of B.1) from guideline B together with an action B' mentioned in the general medical knowledge, because these interventions are not conflicting yet A.3 fulfills the same goals as intervention A.1 and intervention B.3 + B' together fulfill the same goal as B.1). Research purpose: Assessing the correctness and completeness of detection of recommendation-interaction and generation of conflict-free recommendations by a comorbidity-DSS Research question: How will the usage of the comorbidity-DSS affect the completeness and correctness of clinicians regarding (a) detection of interactions between recommendations originating from different clinical guidelines applicable for patients with comorbidities and (b) identification of interventions that fulfill the guidelines' goals and are not conflicting.