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Hypersensitivity clinical trials

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NCT ID: NCT04689399 Completed - Covid19 Clinical Trials

Sensitivity and Specificity of SARS-CoV-2 Rapid Antigen Test Compared to RT-PCR Test

Start date: December 26, 2020
Phase: N/A
Study type: Interventional

This project aims to investigate the sensitivity and specificity of the rapid antigen test compared to RT-PCR test performed on samples from the nasopharynx and the anterior nasal cavity and the oropharynx, respectively.

NCT ID: NCT04678063 Completed - Allergy Clinical Trials

Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Cat Allergic Subjects With Asthma

Start date: April 10, 2017
Phase: N/A
Study type: Interventional

This is a randomized, double blind, cross-over study designed to determine the concentration of airborne cat allergen inducing bronchial response in asthmatic subjects allergic to cat, during allergen exposures in the Alyatec environmental exposure chamber (EEC). The study was also designed to validate the specificity of the asthmatic reaction induced by exposure to airborne cat allergen in Alyatec EEC.

NCT ID: NCT04675619 Completed - Clinical trials for Hypersensitivity Pneumonitis

Evaluation of the Efficacy of Pirfenidone in Progressive Chronic Hypersensitivity Pneumonitis

Start date: December 1, 2019
Phase: Phase 2
Study type: Interventional

This study aims to evaluate the efficacy of pirfenidone in chronic hypersensitivity pneumonitis. This study included 40 adult patients (≥ 18 years) with a diagnosis of chronic progressive hypersensitivity pneumonitis. The included patients were divided into 2 groups 20 patients in each one. Group 1: will receive pirfenidone in addition to the conventional treatment Group 2: will be maintained on conventional treatment. Forced vital capacity (FVC),6 minutes walking test(6MWT), oxygen tension in the arterial blood (PaO2), and St. George's Respiratory Questionnaire (SGRQ ) were measured before and after 6 months of a pirfenidone treatment trial. Results

NCT ID: NCT04673734 Completed - Myelin Integrity Clinical Trials

Scan-rescan Reproducibility of Myelin Sensitive MRI Techniques

Start date: February 5, 2021
Phase:
Study type: Observational

This study is to assess the variation in the measurements of myelin sensitive MRI techniques in both white and grey matter in the brain.

NCT ID: NCT04663880 Completed - Allergy Clinical Trials

Validation of Strasbourg Environmental Exposure Chamber ALYATEC in Mite Allergic Subjects With Asthma

Start date: August 30, 2016
Phase: N/A
Study type: Interventional

This is a randomized, double blind, cross-over study designed to determine the concentration of airborne house dust mite allergen inducing bronchial response in asthmatic subjects allergic to mite, during allergen exposures in the Alyatec environmental exposure chamber (EEC). The study was also designed to validate the specificity of the asthmatic reaction induced by exposure to airborne house dust mite allergen in Alyatec EEC.

NCT ID: NCT04651829 Completed - Atopic Dermatitis Clinical Trials

Suspicion of Non IgE-mediated Cow's Milk Protein Allergy: Prevalence and Evolution

Start date: May 2014
Phase:
Study type: Observational

Cow's milk protein allergy (CMPA) is often evoked in infants, in particular in front of delayed symptoms such as rectal bleeding, atopic dermatitis, excessive crying, reflux, failure to thrive... But in case of non IgE-mediated CMPA, the only way to diagnose this allergy is to proceed to an elimination-reintroduction test over a period of 2 to 4 weeks, to improve symptoms first, and then provoke them. Even if the diagnosis is confirmed, we speculate that non IgE-mediated CMPA has a faster resolution than other CMPA. The first aim of this study is to estimate the prevalence of non IgE-mediated CMPA in a cohort of infants with delayed symptoms which could be relied to a CMPA. The second goal is evaluate the age of tolerance in non IgE-mediated CMPA with oral food challenge for milk ever 2 months after 4 months of age.

NCT ID: NCT04643704 Completed - Celiac Disease Clinical Trials

Quality of Life and Eating Disorders in Children With FPIES, Food Allergy or Celiac Disease

QUALIM
Start date: January 5, 2021
Phase:
Study type: Observational

Food allergies are associated with a decrease in quality of life. Patients with FPIES often have more food avoidance than necessary. The greater the number of avoided foods, the greater the risk of eating disorders. To date, no study about quality of life or assessment of eating difficulties has been performed in a French-speaking pediatric population with FPIES or celiac disease

NCT ID: NCT04642001 Completed - Clinical trials for Dental Hypersensitivity

Association of Two Desensitizing Protocols to Control Dentinal Hypersensitivity in Non-carious Lesions

Start date: August 7, 2019
Phase: N/A
Study type: Interventional

This randomized, double-blind clinical trial evaluated the effect of photobimodulation associated with 8% strontium acetate in the treatment of dentin hypersensitivity in non-carious lesions and analyzed the risk factors with the patient's quality of life.

NCT ID: NCT04620746 Completed - Penicillin Allergy Clinical Trials

Penicillin Allergy Testing in STD Clinics

Start date: June 1, 2021
Phase: Phase 4
Study type: Interventional

Demonstration project to implement penicillin allergy testing in STD outpatients using a questionnaire and pen allergy testing

NCT ID: NCT04616404 Completed - Obesity Clinical Trials

The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects With Newly Detected Impaired Fasting Glycaemia.

Start date: July 26, 2018
Phase: N/A
Study type: Interventional

Impaired fasting glucose (IFG) is a condition that precedes diabetes and increases the risk of developing it. Studies support the hypoglycemic effect of Cynara cardunculus (Cs) extracts due to the content of chlorogenic acid, which is a potent inhibitor of glucose 6-phosphate translocase and of dicaffeoylquinic acid derivatives that modulate the activity of alpha-glucosidase. Given this background, we investigated whether a new highly standardized Cs extract could improve glycaemic control, insulin sensitivity and other metabolic parameters (total, HDL and LDL cholesterol, Triglycerides, ApoB, ApoA, waist circumference, Visceral adipose tissue by DXA) in overweight subjects with newly diagnosed IFG.