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Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose

Hyperglycaemia (Diabetic) Clinical Trial

Official title:
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose: an Intervention Study

Clinical Trial Summary

To investigate whether longer-term improvement of glycemic control in poorly controlled diabetes patients with a 12-week intensified insulin treatment regimen will lead to decreased polyol pathway activity.

Clinical Trial Description

Polyol pathway activity will decrease in diabetic individuals who undergo intensification of their insulin treatment regimens as reflected by lower baseline brain intracellular fructose levels and higher intracellular glutathione levels. Furthermore, following longer-term improved glycemic control, patients may also have down-regulation of the pathway as reflected by decreased production of intracellular fructose in response to hyperglycemic clamp. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03469492
Study type Interventional
Source Yale University
Contact
Status Completed
Phase Early Phase 1
Start date January 18, 2018
Completion date March 20, 2020
View Details
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