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Central Sensitisation and Postoperative Pain

Hyperalgesia Clinical Trial

Official title:
Behavioural and Neurophysiological Measurements for the Assessment of Central Sensitisation and Postoperative Pain

Clinical Trial Summary

One out of 10 patients undergoing surgery develops persistent post-surgical pain (PPSP). Unfortunately, available therapies for treating this pain have limited success. It is therefore of great importance to find strategies to prevent PPSP. The goal of this project is to find new screening tools that identify patients that are at risk for developing PPSP. Tissue injury and inflammation following surgery increase the excitability of spinal nociceptive neurons ("central sensitisation", CS) with pain hypersensitivity as consequence. It is thought that CS plays an important role in persistent pain. The first objective of this project is to assess in human patients if the propensity to develop CS manifested as secondary hyperalgesia before surgery is predictive for PPSP. In addition, we will test if the frequency content of the resting-state EEG reflecting the initial state of the brain will be related to the propensity for developing CS and to the presence of PPSP at two months after surgery.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04220697
Study type Interventional
Source Université Catholique de Louvain
Contact Emanuel van den Broeke, PhD
Phone 003227645467
Email emanuel.vandenbroeke@uclouvain.be
Status Recruiting
Phase N/A
Start date January 29, 2020
Completion date December 31, 2022
View Details
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