COVID-19 Clinical Trial
Official title:
The Regimen of Favipiravir Plus Hydroxychloroquine Can Accelerate Recovery of the COVID-19 Patients With Moderate Severity in Comparison to Lopinavir/Ritonavir Plus Hydroxychloroquine Regimen: an Open-label, Non-randomized Clinical Trial Study
This is an open-label, non-randomized clinical trial study. The number of 40 COVID-19
patients with moderate severity will be admitted in progressive care units (PCUs) and
intensive care units (ICUs) enrolled in the study. The sampling will be purposive and based
on the same independent variables, including age, gender, past medical histories, and the
situation of the patient at the admission day, and ventilator support. The patients will be
allocated into two groups with different regimens. Group "A" (regimen A)will be defined as
Favipiravir 1600 mg a first dose and 600 mg in 3 divided doses daily plus 400 mg in 2 divided
doses of Hydroxychloroquine every day. The group "B" (regimen B) will be contained 400 mg of
Lopinavir/Ritonavirin 2 divided doses plus the first dose (400 mg) of Hydroxychloroquine.
Hydroxychloroquine will not be used for adverse drug reactions. The regimen remained at least
7 up to 10 days.
Data will be analyzed using statistical package for social sciences (SPSS) version 18 (SPSS
Inc. Chicago, IL, USA) for windows. The variables will be compared using independent and
paired T-test for normally distributed variables and Wilcoxon, Chi-square for non-normal
distributed variables. The Kaplan Meier test will be used for survival analysis and the
one-sample Kolmogorov-Smirnov test for the evaluation of distributions.
n/a
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