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HSV-2 Infection clinical trials

View clinical trials related to HSV-2 Infection.

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NCT ID: NCT04294030 Withdrawn - HSV-2 Infection Clinical Trials

NOWDx Test for the Diagnosis of Herpes Simplex Virus Type 2

Start date: March 1, 2023
Phase:
Study type: Observational

This study is designed to compare the performance of the NOWDx HSV-2 Test to a currently marketed device. The intent is to show the rapid test device is comparable to the currently marketed device. The NOWDx HSV-2 Test is intended for qualitatively detecting the presence or absence of human Immunoglobulin G (IgG) class antibodies to HSV-2 in human whole blood to aid in the diagnosis of infection caused by herpes simplex virus type 2 (HSV-2).

NCT ID: NCT04205721 Completed - HIV Infections Clinical Trials

Impact Evaluation of a School-Based Sexuality and HIV Prevention Education Activity in South Africa

Start date: August 8, 2016
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the impact of the new South African Department of Basic Education (DBE) sexuality and HIV education program that uses scripted lesson plans and supporting activities and will be implemented by Education Development Center (EDC). The primary outcomes are the incidence of HSV-2 or pregnancy among a cohort of learners in grade 8 and followed for two years in two provinces of South Africa.

NCT ID: NCT03868644 Completed - HIV/AIDS Clinical Trials

The Impact of VCT and Condom Distribution as HIV Prevention Strategies Among Youth in Kenya

Start date: February 1, 2009
Phase: N/A
Study type: Interventional

The vast majority of new HIV infections occur in sub-Saharan Africa, where nearly 2 million people become infected with HIV/AIDS every year. Forty-five percent of these new HIV infections occur among people under 25 years old, and nearly all of them are due to unprotected sex. Ensuring the adoption of safer sexual behavior among youth is critical to keeping the new generations free of HIV. This research study aims to examine, through a large randomized controlled trial, the impact of two HIV prevention strategies among a youth population in Kenya: Voluntary Counseling and Testing for HIV (VCT), and condom distribution.

NCT ID: NCT03701802 Completed - HIV Infections Clinical Trials

Immunogenetic Modulators of Mucosal Protection From HIV-1

Kinga
Start date: September 27, 2018
Phase:
Study type: Observational

This is a single site, prospective, observational study that seeks to assess changes in mucosal immunity that occur as a result of HIV-1 exposure, HSV-2 infection, and/or pre-exposure prophylaxis (PrEP) usage to prevent HIV-1 acquisition. The study will collect mucosal and peripheral blood samples for a detailed analysis of longitudinal immune responses, while also obtaining samples for genetic characterization to understand how variants in CD101 and UBE2V1 may modulate host mucosal responses and HIV-1 infection risk.

NCT ID: NCT03597243 Recruiting - HIV/AIDS Clinical Trials

Cash Transfer to Adolescent Girls and Young Women to Reduce Sexual Risk Behavior - an Impact Evaluation

CARE
Start date: October 30, 2017
Phase: N/A
Study type: Interventional

Vulnerability to HIV infection in Adolescent Girls and Young Women (AGYW) is mainly influenced by structural factors which mediate through sexual risk behavior. The Sauti program as implementing partner of the DREAMS initiative will provide unconditional cash transfer on quarterly basis to vulnerable AGYW in selected districts of Tanzania. The CARE study will evaluate the impact of this activity through a cluster randomised controlled trial that involves quantitative and qualitative research techniques. The study will inform policy makers on the impact of Cash transfer programs in AGYW as a tool to reduce vulnerability to HIV infection in Adolescent Girls and Young women.

NCT ID: NCT03146403 Terminated - Genital Herpes Clinical Trials

Maintenance Dose Study of GEN-003 in Subjects With Genital Herpes Infection

Start date: May 24, 2017
Phase: Phase 2
Study type: Interventional

The main purpose of this clinical study is to see if a maintenance dose of GEN-003 reduces the number of days that subjects have a genital herpes recurrence. The second purpose of the study is to evaluate the safety and tolerability of a maintenance dose of GEN-003.

NCT ID: NCT03080961 Completed - Genital Herpes Clinical Trials

The VIBLOK SAfety and perFormancE Trial

SAFE
Start date: March 27, 2017
Phase: N/A
Study type: Interventional

Genital herpes has a high prevalence in industrialized as well as developing countries. Genital herpes causes genital ulcers, increases risk for acquiring HIV infection, and may be transmitted mother to child during birth with possible serious consequences. Medical treatments and condoms only partially reduce the risk for transmission from/ to sexual partners. Genital herpes transmission despite use of condoms is thought to be due to transfer via skin-to-skin contact in unprotected areas, and HSV-2 transmission may be enhanced by current shaving habits in the genital area leading to micro lesions (lacerations) of the skin. VIBLOK™ is a cream designed to impede the passage of viruses, such as HSV-2, across the skin. Bench and animal experiments indicate that it can block virus transmission such as HSV-2 over 80%. The objective of the SAFE trial is to assess the safety and performance of VIBLOK in adults with HSV-2 infection by comparing virus detection in the extra-genital area before and after application of the barrier cream.

NCT ID: NCT02986802 Completed - PreTerm Birth Clinical Trials

Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes

PCORIHSV
Start date: March 14, 2017
Phase:
Study type: Observational
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