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Safety and Immunogenicity Following Meningococcal and Pneumococcal Immunization Among Adult People Living With HIV — MENPI  

Hiv Clinical Trial

Official title:
Safety and Immunogenicity Following Meningococcal and Pneumococcal Immunization Among Adult People Living With HIV: A Single Center, Non-blinded, Randomized Clinical Trial

Clinical Trial Summary

MENPI is an investigator-initiated single-centre randomized controlled trial which aims to assess the efficacy and safety of meningococcal and pneumococcal vaccination in adults living with HIV receiving antiretroviral treatment. Participants are randomized 1:1 to either a two-dose Menveo® and Bexsero® regimen or a Prevenar13®/Pneumovax23® prime-boost regimen at day 0 and day 60 and cross over on day 90. All participants will follow an identical follow up program including plasma collection, pharyngeal swab, and adverse event registration. Immunogenicity will be determined on venous blood sampled at 30 days post-vaccination and yearly for five years.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04875819
Study type Interventional
Source Hvidovre University Hospital
Contact Michaela Tinggaard, M.D.
Phone 22326800
Email michaela.tinggaard@regionh.dk
Status Recruiting
Phase Phase 4
Start date April 28, 2021
Completion date December 2026
View Details
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