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The Effect of Probiotics on Microbial Translocation and Inflammation in HIV-infected Patients

HIV Clinical Trial

Official title:
The Effect of Probiotics on Microbial Translocation and Inflammation in HIV-infected Patients

Clinical Trial Summary

Objective:

In this study the investigators aim at investigating:

1. probiotics ability to modulate the microbiome and microbial translocation,

2. if probiotics affect the level of cholesterol, triglycerides as markers of cardiovascular risk factors and

3. if a reduction of microbial translocation is associated with a reduction of inflammation in the gastro-intestinal tract.

Design:

The study is a prospective clinical intervention trial of 40 HIV-infected patients.

Method:

The investigator will administer the bacteria Lactobacillus Rhamnosus in capsular form to each patient 2 times a day in 8 weeks. At baseline and at the 8th week of the intervention, the investigators will collect blood samples, feces samples and make a positron emission tomography-magnetic resonance scans.

Clinical Trial Description

n/a

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02764684
Study type Interventional
Source Rigshospitalet, Denmark
Contact
Status Completed
Phase N/A
Start date January 2015
Completion date September 2016
View Details
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