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NCT02858414 Clinical Trial

Exploratory Study of Cellular Reservoirs in Blood From HIV Infected Patients

HIV Infection Clinical Trial

— EURECA  

Official title:
Exploratory Study of Cellular Reservoirs in Blood From HIV Infected Patients: EURECA (ERANET to Unravel New Roads to Eradication and a Cure for AIDS) Study

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02858414
Other study ID # P/2014/223
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date April 2, 2015
Est. completion date October 4, 2017

Study information
Verified date December 2018
Source Centre Hospitalier Universitaire de Besancon
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study evaluates the impact of highly active antiretroviral therapy on the size of the latent viral reservoirs in resting CD4+ T cells and monocytes in HIV positive patients. The activation state of the cells will be assessed, by measuring the activation of Akt, to determine its influence on the size of the viral reservoirs.

Recruitment information / eligibility
Status Completed
Enrollment 41
Est. completion date October 4, 2017
Est. primary completion date October 4, 2017
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- HIV infected patients under Highly Active Anti-Retroviral Therapy (HAART) or Naïve from treatment

Exclusion Criteria:

- Age limits

- Pregnancy

- Legal restrictions to consent

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• additional blood sample

Locations
Country Name City State
France Centre Hospitalier Régional Universitaire Besançon

Sponsors (1)
Lead Sponsor Collaborator
Centre Hospitalier Universitaire de Besancon

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Measure of the integrated viral reservoir size Measure by Alu-PCR. Results are given in number of integrated proviral DNA copies per 1 million cells. day 1
Primary Measure of the proviral reservoir size Measure by Total Proviral HIV DNA detection kit. Results are given in number of total proviral DNA copies per 1 million cells. day 1
Secondary Measure of Akt activation Measure of Akt activation in live cells by flow cytometry day 1
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