HIV Infection Clinical Trial
Official title:
Population Genetics and Immune Response to Hepatitis B Vaccination in Adolescents: A Substudy of ATN 024 and ATN 025
This laboratory-based substudy of an effectiveness trial of two Hepatitis B vaccines in HIV-negative youths is being done to evaluate the genetic contribution to the individualized immune response.
This laboratory-based substudy of ATN 024 and 025 will evaluate the genetic contribution to
highly individualized immune responses to hepatitis B vaccine in individuals and confirm the
correlation of specific human leukocyte antigen (HLA) alleles and haplotypes with Hepatitis
B Virus (HVB) antibody concentrations and antibody decay kinetics in vaccinated adolescents.
Approximately 5 ml of whole blood will be collected from study participants at the time of
the week 28 visit or at any subsequent study visit or clinic visit following successful
completion of the week 28 visit. Peripheral blood mononuclear cells will be obtained and QIA
amp Blood kit will be used to extract high-quality genomic DNA for polymerase chain
reaction-based genotyping by the PEII laboratory.
The study is expected to be available for the duration of the parent studies which is
approximately 2 years. This study requires one visit that may be arranged to coincide with a
study or routine clinic visit. There are no follow up visits.
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