HIV/AIDS Clinical Trial
Official title:
Addressing the Continuum of Care Among High-risk Thai Men
Verified date | May 2024 |
Source | Mahidol University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Young Thai men who have sex with men (YMSM) are at high risk for HIV. However, the Thailand National HIV Strategy does not adequately cover HIV prevention for YMSM using specific methods relevant to them, and instead uses a one-size-fits all approach. Partnering with the Thailand Ministry of Public Health (MOPH), the proposed study seeks to finalize, implement and evaluate a multicomponent, multi-level, community mobilization, combination intervention (HUG-M+) to address the entire Continuum of Prevention and Care. The investigators propose to test the efficacy of this approach by conducting research in two Northeastern Thai cities, one randomized to the intervention condition, which will receive HUG-M+ and the other to the control condition, where standard of care will be provided. If HUG-M+ is found to be efficacious, it might be scaled up, with the support of the MOPH, to other regions in Thailand, elsewhere in Asia and the US.
Status | Active, not recruiting |
Enrollment | 636 |
Est. completion date | May 31, 2025 |
Est. primary completion date | May 31, 2025 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 15 Years to 29 Years |
Eligibility | Inclusion Criteria: - Age 15-29 years at cohort baseline - Self-reported male gender - Self-reported having had anal sex with another man in the past 12 months - Speak, read and write Thai - Thai citizenship - Resident of the assessment city for the next 2 years (live, work or go to school) Exclusion Criteria: - Do not consent to urine testing or anal swab - Not willing to give contact information for follow-up assessments |
Country | Name | City | State |
---|---|---|---|
Thailand | M-Health Office Maha Sarakham | Maha Sarakham | |
Thailand | M-Health Office Ubon | Ubon Ratchathani |
Lead Sponsor | Collaborator |
---|---|
Mahidol University | National Institute of Mental Health (NIMH), University of California, San Francisco, University of Malaya |
Thailand,
Guadamuz TE, Boonmongkon P. Ice parties among young men who have sex with men in Thailand: Pleasures, secrecy and risks. Int J Drug Policy. 2018 May;55:249-255. doi: 10.1016/j.drugpo.2018.04.005. Epub 2018 Apr 23. — View Citation
Guadamuz TE, Goldsamt LA, Boonmongkon P. Consent Challenges for Participation of Young Men Who Have Sex With Men (YMSM) in HIV Prevention Research in Thailand. Ethics Behav. 2015 Mar;25(2):180-195. doi: 10.1080/10508422.2014.949721. — View Citation
Guadamuz TE, McCarthy K, Wimonsate W, Thienkrua W, Varangrat A, Chaikummao S, Sangiamkittikul A, Stall RD, van Griensven F. Psychosocial health conditions and HIV prevalence and incidence in a cohort of men who have sex with men in Bangkok, Thailand: evidence of a syndemic effect. AIDS Behav. 2014 Nov;18(11):2089-96. doi: 10.1007/s10461-014-0826-8. — View Citation
Kongjareon Y, Samoh N, Lim SH, Peerawaranun P, Jonas KJ, Guadamuz TE. Group sex, suicidality and online partners: implications for HIV and suicide prevention: a short report. AIDS Care. 2020 Aug;32(8):954-958. doi: 10.1080/09540121.2020.1734174. Epub 2020 Mar 12. — View Citation
Samoh N, Peerawaranun P, Jonas KJ, Lim SH, Wickersham JA, Guadamuz TE. Willingness to Use HIV Self-Testing With Online Supervision Among App-Using Young Men Who Have Sex With Men in Bangkok. Sex Transm Dis. 2021 Mar 1;48(3):e41-e44. doi: 10.1097/OLQ.0000000000001271. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of participants who have tested for HIV the past 6 months | Participants will answer a yes/no question if they have tested in the past 6 months | 6 months | |
Primary | Number of participants who have engaged in condomless anal intercourse in the past 6 months | Participants will answer a yes/no question if they engage in condomless anal intercourse (CAI) with non-primary or primary partners who are serodiscordant or of unknown serostatus, nonmonogamous, or who have been primary partners less than 6 months. | 6 months | |
Secondary | Number of participants who report using PrEP daily or on demand | Participants will answer a series of questions related to PrEP use and patterns of use (either daily or on demand) | 6 months | |
Secondary | Undetectable viral load | Self-reported undetectable viral load | 6 months | |
Secondary | HIV prevalence | HIV prevalence at baseline | baseline | |
Secondary | HIV incidence/seroconversion | HIV incidence/seroconversion | 6 months | |
Secondary | STI incidence | Chlamydia and gonorrhoea by urine and anal swab | 6 months |
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