HIV-1 Infections Clinical Trial
Official title:
Optimisation of Primary HIV1 Infection Treatment (ANRS 147 OPTIPRIM)
The purpose of this trial is to assess the impact of raltegravir, maraviroc, darunavir/r, and Truvada® (emtricitabine/tenofovir) vs. darunavir/r and Truvada® on cell-associated HIV-DNA levels in patients with primary HIV-1 infection.
Primary HIV-1 infection is characterized by a phase of intense replication, with a quick
dissemination and early changes in the immune system. During primary HIV-1 infection,
damages to MALT and GALT promotes a chronic cell activation, which participates in a
progressive decay of immune functions.
After HAART initiation, the magnitude and rapidity of cell-associated HIV-DNA decrease are
significantly higher in patients with primary HIV-1 infection than in patients with chronic
infection (Ngo Giang Huong, AIDS 2004).
We hypothesize that an early intervention at different levels of viral replication with
potent and well-tolerated new drugs may have a greater impact on cell-associated HIV-DNA
levels than conventional triple-drug HAART.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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