| Eligibility |
Inclusion Criteria:
1. Males and females, age =18 years;
2. HIV-1 seropositive, with documented HIV-1 infection by official, signed, written
history (eg. Laboratory report);
3. Receiving a combination antiretroviral therapy (cART) (failing regimen) for at least 8
weeks before Screening and are willing to continue on the failing regimen during the
Screening Phase and up to Day 14 of the Treatment Phase, OR have failed in the past 8
weeks of Screening and are off therapy and are willing to stay off therapy until Day
14 of the Treatment Phase;
4. Plasma HIV-1 RNA = 1000 copies/mL at the Screening Visit and documented detectable
viral load (HIV-1 RNA >200 copies/ml) within the last 3 months prior to the Screening
Visit;
5. Highly treatment-experienced HIV-infected patients with documented genotypic and/or
phenotypic resistance to at least one ARV drug within three or more drug classes of
antiretroviral medications and have difficulty in constructing a viable suppressive
regimen.
6. Have full viral sensitivity/susceptibility to at least one approved antiretroviral
agent, other than UB-421, as determined by genotypic and/or phenotypic ARV drug
resistance tests at screening, and such agent can be used as a component of OBT;
7. Be willing to remain on treatment without any changes or additions to the OBT regimen,
except for toxicity management or upon meeting criteria for treatment failure;
8. Have a life expectancy that is > 9 months;
9. Laboratory values at Screening of:
1. Absolute neutrophil count (ANC) = 750/mm3;
2. Hemoglobin (Hb) = 10.5 gm/dL (male) or = 9.5 gm/dL (female);
3. Platelets = 75,000 /mm3;
4. Serum alanine transaminase (SGPT/ALT) < 2.5 x upper limit of normal (ULN);
5. Serum aspartate transaminase (SGOT/AST) < 2.5 x ULN;
6. Bilirubin (total) < 2.5 x ULN unless Gilbert's disease is present or subject is
receiving atazanavir in the absence of other evidence of significant liver
disease; and
7. Creatinine = 1.5 x ULN
10. Clinically normal resting 12-lead electrocardiogram (ECG) at the Screening Visit or,
if abnormal, considered not clinically significant by the Principal Investigator.
11. Both male and female patients and their partners of childbearing potential must agree
to use 2 medically accepted methods of contraception (e.g., barrier contraceptives
[male condom, female condom, or diaphragm with a spermicidal gel], hormonal
contraceptives [implants,injectables, combination oral contraceptives, transdermal
patches, or contraceptive rings], and intrauterine devices) during the course of the
study (excluding women who are not of childbearing potential and men who have been
sterilized). Females of childbearing potential must have a negative serum pregnancy
test at the Screening Visit and negative urine pregnancy test prior to receiving the
first dose of study drug; and
12. Willing and able to participate in all aspects of the study, including use of IV
medication, completion of subjective evaluations, attendance at scheduled clinic
visits, and compliance with all protocol requirements as evidenced by providing
written informed consent.
Exclusion Criteria:
1. Any currently active AIDS-defining illness per Category C conditions according to the
Center for Disease Control (CDC) Classification System for HIV Infection, with the
following exceptions: local cutaneous Kaposi's sarcoma, wasting syndrome due to HIV or
any other AIDS-defining illness for which no therapeutic treatment is required OR the
required treatment is not included in the list of prohibited medications;
2. Subjects with baseline liver disease including active Hepatitis B or C infection or
any other active infection secondary to HIV requiring acute therapy;
3. Subjects with baseline CD4 counts < 350 cells/mm^3.
4. Any = Grade 3 laboratory abnormality according to the division of AIDS grading scale;
5. Unexplained fever or clinically significant illness within 2 weeks prior to the first
dose of study drug;
6. Any vaccination within 2 weeks prior to the first dose of study drug;
7. Any immunomodulating therapy (excluding pre-medication steroid) or systemic
chemotherapy within 4 weeks prior to the Screening Visit;
8. Any radiation therapy within 4 weeks prior to the Screening Visit;
9. Any previous exposure to monoclonal antibody for the treatment of HIV within 12 weeks
prior to the Screening Visit (excluding ibalizumab);
10. Participation in an experimental drug trial(s) within 4 weeks prior to the Screening
Visit;
11. Any prior exposure to UB-421;
12. Females who are pregnant, lactating, or breastfeeding, or who plan to become pregnant
during the study; and
13. Any significant diseases (other than HIV-1 infection) or clinically significant
findings that, in the Investigator's judgment, would potentially compromise study
compliance or the ability to evaluate safety/efficacy.
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