HIV-1 Infection Clinical Trial
Official title:
Effects of Losartan and Antiretroviral Regimen Containing Raltegravir in Fibrosis Inflammation
This is a open controlled trial in which 48 HIV-1 patients successfully treated with
EFV/FTC/TDF will be randomized to one of 4 groups in equal proportion between arms (1:1). The
four arms are as follows:
Arm I: EFV / FTC / TDF (n = 12) Arm II: EFV / FTC / TDF + LST (n = 12) Arm III: FTC / TDF +
MK-0518 (n = 12) Arm IV: FTC / TDF + LST + MK-0518 (n = 12)
The allocation will take place in two phases:
Phase I: 24 patients 1:1 receiving EFV/FTC/TDF vs. EFV/FTC/TDF + Losartan
If losartan arm shows benefits we will proceed to the second phase:
Phase II: 24 patients 1:1 to receive FTC/TDF+ MK-0518 versus FTC/TDF + MK-0518 + losartan.
Patients will be followed up during 12 months to determinate the proportion of patients with
decreased collagen deposition in TL equal to or greater than 50%.
n/a
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