Oral and Perioral Herpes Simplex Virus Infection Type I in a Five-month-old Infant: A Case Report

Herpes Simplex Virus Infection Clinical Trial

Official title:

Oral and Perioral Herpes Simplex Virus Infection Type I in a Five-month-old Infant: A Case Report

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04713423
• Other study ID #: PrincessNBAU
• Status: Completed
• Start date: October 19, 2017
• Est. completion date: October 19, 2017

Study information

• Verified date: January 2021
• Source: Princess Nourah Bint Abdulrahman University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

A five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral vesicles.

Description:

The investigators present the case of a five-month-old healthy girl who presented with painful herpetic gingivostomatitis and perioral vesicles. The investigators discuss the pathophysiology of primary herpes simplex virus infection and the effect of maternal antibodies on the infant's immune system. In addition, the investigators explain the diagnosis, management, and prognosis of herpes simplex virus infection in young infants.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1
• Est. completion date: October 19, 2017
• Est. primary completion date: October 19, 2017
• Accepts healthy volunteers: No
• Gender: Female
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Five-months-old infants or younger

Exclusion Criteria:

• Six-months-old infants or older

Related Conditions & MeSH terms

• Communicable Diseases
• Herpes Simplex
• Herpes Simplex Virus Infection
• Infection
• Virus Diseases

Intervention

Diagnostic Test:
• Diagnosis and treatment of the case
The infant was transferred to a hospital for better management of her infection. She was immediately started on intravenous acyclovir (20 mg/kg/6 h/5 d) while acetaminophen suppositories (80 mg/8 h/5 d) were given to lower her body temperature. In addition, other palliative drugs, such as diphenhydramine syrup (12.5 mg/5 mL, 2.5 mL orally) once-a-night for five days, were given to ease the effort of drinking and to aid in achieving good sleep. Upon completion of five days of therapy, the patient showed complete recovery and was subsequently discharged from the hospital free from symptoms.

Locations

Country	Name	City	State
Saudi Arabia	Princess Nourah Bint Abdulrahman University	Riyadh

Sponsors (1)

Lead Sponsor	Collaborator
Princess Nourah Bint Abdulrahman University

Country where clinical trial is conducted

Saudi Arabia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Health condition	Number of tests were performed and different drugs were administered	one week