Clinical Trials Logo

Clinical Trial Summary

Valacyclovir has replaced acyclovir in many clinical scenarios. Pharmacokinetic data support the use of oral valacyclovir in children, but practical problems exist in children having to take adult-dose tablets. A formulation with acceptable palatability, good pharmaceutical quality and possibility of flexible dosing is developed. Pharmacokinetic data of this formulation is missing. The present study investigates the pharmacokinetics of valacyclovir oral solution in children by determine the area under the curve (AUC0-12), time above critical concentration (Ccrit), Cmax and Tmax of acyclovir. Secondary, the safety profile of a single dose of valacyclovir oral solution will be determined.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04081480
Study type Interventional
Source Radboud University
Contact
Status Terminated
Phase N/A
Start date December 10, 2019
Completion date May 12, 2021

See also
  Status Clinical Trial Phase
Completed NCT01682109 - Palatability Testing of a New Paediatric Formulation of Valacyclovir Phase 4
Recruiting NCT05198570 - Pharmacokinetics of Intravenous Acyclovir in Oncologic Paediatric Patients
Not yet recruiting NCT06409494 - Clinical Trial to Evaluate EuHZV in Healthy Adults Aged 50 to 69 Years Phase 1
Recruiting NCT05604911 - Herpes Virus Infections in Kidney Transplant Patients
Recruiting NCT05532540 - Herpesvirus Immunology in Solid Organ Transplant Recipients - Liver Transplant Study
Not yet recruiting NCT05664152 - An Open-label, Bridging Study of BARYCELA Inj. in Healthy Vietnamese Children Aged Between 12 Months to 12 Years N/A
Completed NCT01689285 - Bioequivalence Study in Healthy Volunteers of a New Paediatric Formulation of Valacyclovir Phase 1
Recruiting NCT04403139 - VZV-specific Tissue Resident Memory T-cells After Shingrix Vaccination Phase 4