Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

Hepatopulmonary Syndrome Clinical Trial

Official title:

Effect of Transjugular Intrahepatic Portosystemic Shunt on Oxygenation in Cirrhotic Patients With Hepatopulmonary Syndrome

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02148536
• Other study ID #: WCH-2014-034
• Status: Completed
• Start date: June 2014
• Est. completion date: September 2015

Study information

• Verified date: August 2018
• Source: West China Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

To prospectively investigate the effect of transjugular intrahepatic portosystemic shunt (TIPS) on oxygenation in cirrhotic patients with hepatopulmonary syndrome (HPS).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 64
• Est. completion date: September 2015
• Est. primary completion date: June 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Presence of cirrhosis

• Alveolar-arterial oxygen gradient = 15 mm Hg (= 20 mm Hg for age > 64 years)

• Positive contrast-enhanced echocardiography

Exclusion Criteria:

• Age of less than 18 years

• Intrinsic cardiopulmonary disease

• Malignancy

• Active infection

• Pregnancy

• Previous shunt therapy

• Refusal to participate

Related Conditions & MeSH terms

• Hepatopulmonary Syndrome
• Syndrome

Intervention

Procedure:
• Transjugular intrahepatic portosystemic shunt

Locations

Country	Name	City	State
China	West China Hospital, Sichuan university	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
West China Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Alveolar-arterial oxygen gradient (PA-a,O2)		12 Weeks
Secondary	Macroaggregated albumin (MAA) shunt fraction		12 Weeks
Secondary	Exhaled nitric oxide (eNO)		12 Weeks