| Eligibility |
Inclusion Criteria:
- 1. Non resectable advanced hepatocellular carcinoma confirmed by pathological and
clinical imaging examinations.
- 2. Patients who have previously received systematic treatment combined with failed or
intolerable interventional therapy.
- 3. Male or female, aged = 18 years at the time of signing the Informed consent form
(ICF).
- 4. The liver should have at least one measurable target lesion (RECIST v1.1). If it is
an active lesion after local treatment (radiotherapy, ablation, transcatheter arterial
chemoembolization, etc.), local treatment should be completed 4 weeks before the
screening period imaging examination.
- 5. The patient's Eastern Oncology Collaborative Group (ECOG) physical condition score
is 0 or 1.
- 6. The patient's organ and blood system functions meet the requirements:
1. Hematology function: Absolute neutrophil count (ANC) = 1.5 x 10 ^ 9/L, platelet
count = 75 x 10 ^ 9/L
2. Adequate renal function: serum creatinine<1.5x ULN or creatinine clearance
rate>40 mL/min (Cockcroft Fault formula)
3. Liver function: Total bilirubin = 1.5 x ULN, Aspartate aminotransferase (AST) and
Alanine aminotransferase (ALT) = 5 x ULN
4. Coagulation function: Within the normal range of Prothrombin time (PT) .
- 7. Female participants with Fertility need to carry out serum pregnancy test within 72
hours before starting the study drug administration, and the result is negative, and
take effective contraceptive measures (such as Intrauterine device, contraceptive pill
or pregnancy avoidance condom) during the test period and at least 3 months after the
last administration; For male participants whose partners are Fertility women, they
should be surgically sterilized or agree to take effective contraceptive measures
during the trial period and within 3 months after the last administration.
- 8. The participants have good compliance and cooperate with follow-up.
Exclusion Criteria:
- 1. Has a history of allergies to any component of the study drug in the past;
- 2. Known to be allergic to Programmed Death-1/Programmed Death-L1 (PD-1/PD-L1)
antibodies or have experienced drug-related Immune related adverse events (irAEs) in
the past, in accordance with the "Guidelines Of Chinese Society Of Clinical Oncology
[CSCO]Management Of Immune Checkpointinhibitor-Related Toxicity 2019", it meets the
indication for permanent discontinuation of medication;
- 3. There are known Contraindication of percutaneous hepatic artery infusion;
- 4. Has received or is currently receiving any of the following treatments in the past:
1. The patient underwent major surgical procedures within 14 days prior to entering
the study (puncture biopsy is not included)
2. Previous or planned immune therapy such as Chimeric antigen receptor T cell
immunotherapy (CAR-T) and vaccines
- 5. Have any active autoimmune disease or history of autoimmune disease, including but
not limited to interstitial pneumonia, enteritis, hepatitis, hypophysitis, Vasculitis,
nephritis, hyperthyroidism, hypothyroidism (it can be considered to be included after
hormone replacement treatment); Patients with psoriasis or childhood asthma/allergy
that has completely alleviated and does not need any intervention after adulthood can
be considered for inclusion, but patients who need medical intervention with
Bronchiectasis cannot be included;
- 6. Poor nutritional status, BMI<18.5 Kg/m2; If symptomatic nutritional support is
provided and corrected before enrollment, and evaluated by the main investigator,
enrollment can continue to be considered;
- 7. Have a history of immune deficiency, including positive Diagnosis of HIV/AIDS, or
have other acquired or congenital immune deficiency diseases, or have a history of
organ transplantation or allogeneic bone marrow transplantation;
- 8. There are clinical symptoms or diseases of the heart that cannot be well
controlled, including but not limited to: (1) New York Heart Association (NYHA)grade
II or above heart failure, (2) unstable angina pectoris, (3) myocardial infarction
within 1 year, (4) clinically significant supraventricular or ventricular arrhythmias
that have not undergone clinical intervention or are still poorly controlled after
clinical intervention;
- 9. Serious infection (CTCAE>grade 2) occurred within 4 weeks before the first use of
the study drug, such as severe pneumonia, Bloodstream infections, infection
complications, etc. requiring hospitalization; Baseline chest imaging examination
indicates the presence of active pulmonary inflammation, symptoms and signs of
infection within 14 days prior to the first use of the study drug, or the need for
oral or intravenous antibiotic treatment, excluding prophylactic use of antibiotics;
- 10. Those who have been found to have active pulmonary tuberculosis infection through
medical history or CT examination, or have a history of active pulmonary tuberculosis
infection within 1 year before enrollment, or have a history of active pulmonary
tuberculosis infection more than 1 year before but have not received formal treatment;
- 11. There is active hepatitis B (HBV DNA = 2000 IU/mL or 104 copies/mL) and hepatitis
C (hepatitis C antibody is positive, and HCV RNA is higher than the detection limit of
the analytical method);
- 12. Other malignant tumors were diagnosed within 5 years before the first use of the
study drug, except for malignant tumors with low risk of metastasis or death (5-year
survival rate>90%), such as fully treated skin Basal-cell carcinoma or squamous cell
skin cancer or cervical Carcinoma in situ, which can be considered to be included in
the group;
- 13. Pregnant or lactating women;
- 14. Previous history of hypertensive crisis or hypertensive encephalopathy;
- 15. Use Nonsteroidal anti-inflammatory drug (NSAIDs) for long-term daily treatment;
- 16. Untreated or incompletely treated esophageal and/or gastric varices with high risk
of bleeding or bleeding;
- 17. Previous bleeding events caused by esophageal and/or gastric varices within 6
months prior to the start of the study treatment;
- 18. According to the judgment of the investigators, there are other factors that may
lead to forced termination of the study, such as suffering from other serious
illnesses (including mental illness) requiring concurrent treatment, alcoholism, drug
abuse, family or social factors, which may affect the safety or compliance of the
participants.
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