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Clinical Trial Summary

The purpose of this research study is to compare the effectiveness and safety of two standard of care treatments in people who have been diagnosed with hepatocellular carcinoma (HCC).This research study is being done to compare atezolizumab/bevacizumab to locoregional therapy with either transarterial chemoembolization (TACE) or transarterial radioembolization (TARE).


Clinical Trial Description

To evaluate the efficacy and safety of atezolizumab and bevacizumab compared to locoregional therapy (TACE or TARE) in patients with intermediate-stage HCC. The primary outcome is progression-free survival, which will be compared between two arms using stratified log-rank tests, adjusting the effect of stratification variables between two study arms. Cox regression analysis will be done to see if there are significant differences in PFS, controlling for the effects of confounding variables between the two study arms. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05537402
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Ellen Siglinsky
Phone 214-648-7097
Email Ellen.Siglinsky@UTSouthwestern.edu
Status Recruiting
Phase Phase 2
Start date September 27, 2023
Completion date January 1, 2028

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