Hepatocellular Carcinoma Clinical Trial
Official title:
A Multicentre Randomized Controlled Study of Anti-angiogenic Targeted Drugs Combined With Ginsenoside Rg3 to Improve the Efficacy of Transcatheter Arterial Chemoembolization (TACE) in the Treatment of Unresectable Hepatocellular Carcinoma
The aim of this study is to compare the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with the anti-angiogenic targeted drugs and ginsenoside Rg3 versus TACE alone in patients with unresectable Barcelona Clinic Liver Cancer (BCLC) stage B/C hepatocellular carcinoma (HCC), who has normal liver function and no extrahepatic metastasis.
TACE is widely used in patients with unresectable HCC, which has been proved to significantly
improve the survival time by the results from some randomized controlled studies and
meta-analyses. However, due to the different blood supply characteristics and biological
heterogeneity in HCC nodules, the therapeutic effect of TACE is limited, and which is still
considered as a non-radical treatment. Furthermore, vascular embolization by TACE may result
in hypoxia in tumor tissue, which will induce increased secretion of angiogenic factors such
as vascular endothelial growth factor (VEGF) and tumor angiogenesis, promote proliferation of
residual tumor cells, and enhance tumor invasive and metastasis. Accordingly, the
effectiveness of TACE is still unsatisfying as a single treatment for HCC.
Both anti-angiogenic targeted drugs and ginsenoside Rg3 have showed synergistic effect with
TACE in patients with unresectable HCC. The purpose of this trial is to evaluate the efficacy
and safety of the combination of anti-angiogenic targeted drugs and ginsenoside Rg3 plus TACE
comparing to TACE alone in patients with unresectable HCC.
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