Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
The study will compare OSA prevalence in a group of patient curatively resected for NASH-related HCC with a group of HCV-related HCC. |
Number of patient presenting an obstructive apnea syndrome diagnosed by oxymetry |
2 years |
|
Secondary |
The study will compare the 3% oxygen desaturation index between groups. |
3% IDO represents the number of oxygen desaturation of at least 3% per hour of oxymetry recording, measured by one oximetry measurement during a single night at the patient's home. |
2 years |
|
Secondary |
The study will compare the 2% oxygen desaturation index between groups. |
2% IDO represents the number of oxygen desaturation of at least 2% per hour of oxymetry recording, measured by one oximetry measurement during a single night at the patient's home. |
2 years |
|
Secondary |
The study will compare the 4% oxygen desaturation index between groups. |
4% IDO represents the number of oxygen desaturation of at least 4% per hour of oxymetry recording, measured by one oximetry measurement during a single night at the patient's home. |
2 years |
|
Secondary |
This study will compare the number of micro-arousals between groups. |
Micro-arousals associated with desaturation will be measured to characterize sleep fragmentation |
2 years |
|
Secondary |
This study will compare the time spent with a saturation less than 90 % between groups. |
The time spent with a saturation less than 90 % (Tsat90 in second) to characterize oxygen desaturations and OSA severity |
2 years |
|
Secondary |
This study will compare the Pittsburgh Sleep Quality Index (PSQI) between groups. |
The Pittsburgh Sleep Quality Index (PSQI) is a self-report questionnaire that assesses sleep quality. Consisting of 19 items, the PSQI measures several different aspects of sleep. Each item is weighted on a 0-3 interval scale. The global PSQI score is then calculated by totaling the seven component scores, providing an overall score ranging from 0 to 21, where lower scores denote a healthier sleep quality. |
2 years |
|
Secondary |
This study will compare the Epworth Sleepiness Score between groups. |
The Epworth sleepiness scale (ESS) is a self-administered questionnaire that's routinely used by doctors to assess daytime sleepiness. The person filling in the questionnaire rates how likely they are to doze off during the day in 8 different situations.The test evaluate the tendency to become sleepy on a scale of 0, no chance of dozing, to 3, high chance of dozing. |
2 years |
|
Secondary |
The study will compare the prevalence of OSA in patients with NASH-induced CHC with cirrhotic context compared to NASH-induced CHC patients without cirrhosis. |
Number of patient presenting an obstructive apnea syndrome diagnosed by oxymetry in both subpopulations: cirrhotic and non-cirrhotic. |
2 years |
|
Secondary |
The study will compare the NAFLD Activity Score (NAS score) between OSA and non-OSA subgroups of NASH patients. |
NAFLD Activity Score includes the degree of steatosis, hepatocyte ballooning, lobular inflammation and fibrosis. Nas score is between 0 and 16. |
2 years |
|
Secondary |
The study will compare the Brunt score between OSA and non-OSA subgroups of NASH patients. |
The Brunt score for NASH patients is used to evaluate fibrosis stage. The score is between 1 and 4. |
2 Years |
|
Secondary |
The study will compare the METAVIR score data between HCV OSA and HCV non-OSA patients. |
The METAVIR score is used to evaluate fibrosis stage for HCV patients. The score is between 0 and 4. |
2 Years |
|
Secondary |
The study will compare BCLC classification of HCC tumor between groups. |
Tumor stage evaluated by BCLC classification scale :0,A,B,C and D values (0 for Stage 0 Very early stage, D for terminal stage) |
2 years |
|
Secondary |
The study will compare HCC tumor size between each groups. |
Tumor size (expressed in cm) is asociated to HCC prognostic the size of the tumor is associated with the prognosis of the HCC |
2 years |
|
Secondary |
The study will compare HCC tumor differentiation degree between groups. |
The tumor differentiation is classified in 3 levels: low, moderate or high level of tumor differentiation |
2 years |
|
Secondary |
The study will compare vascular invasion of HCC tumor between groups. |
Presence or absence of tumor vascular invasion |
2 years |
|
Secondary |
The study will compare the number of satellite nodules of HCC between between groups. |
Number of tumoral satellite nodules (multifocality) |
2 years |
|
Secondary |
The study will compare plasma alpha fetoprotein level between groups. |
Plasma alpha fetoprotein (AFP) level expressed in ng/ml |
2 years |
|
Secondary |
The study will compare overall survival rate between groups. |
Overall survival at 1 and 2 years will be collected. |
2 years |
|
Secondary |
The study will compare tumor-free survival rate between groups. |
Tumor-free survival at 1 and 2 years will be collected. |
2 years |
|
Secondary |
The study will compare non-recurrence-free survival rate between groups. |
Non-recurrence-free survival at 1 and 2 years will be retrospectively or prospectively collected. |
2 years |
|