GPC3-targeted CAR-T Cell for Treating GPC3 Positive Advanced HCC

Status Recruiting

Clinical Trial Summary

Patients with hepatocellular carcinoma (a type of primary liver cancers) are enrolls in this study. The cancer has progressed after standard treatment, or the patient cannot receive regular treatment. Investigator made a gene called chimeric antigen receptor derived from an antibody that recognizes Glypican 3, a protein detected in in a large proportion of hepatocellular carcinoma. The gene will introduce into T cell from patient's blood to make them recognize and kill cancer cells. The aim of this study is to evaluate the efficacy, tolerance and safety of chimeric antigen receptor-modified T (CAR-T) cell targeting Glypican 3 for advanced hepatocellular carcinoma.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04121273
Study type	Interventional
Source	The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact	Decai Yu, MD
Phone	8613701585023
Email	yudecai@nju.edu.cn
Status	Recruiting
Phase	Phase 1
Start date	October 5, 2019
Completion date	November 1, 2021

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