Hepatocellular Carcinoma Clinical Trial
Official title:
Role of LDH as a Predictor of Treatment Outcomes in Hepatocellular Carcinoma
Hepatocellular carcinoma represents the commonest primary cancer of the liver.serum lactate dehydrogenase is an indirect marker of tumor hypoxia,angioneogenesis and worse prognosis.
Hepatocellular carcinoma (HCC) represents the commonest primary cancer of the liver.
Incidence is increasing and HCC has risen to become the 5th commonest malignancy worldwide
and the third leading cause of cancer related death, exceeded only by cancers of the lung and
stomach. HCC prevalence is higher in sub-Saharan Africa, central and Southeast Asia.Serum
lactate dehydrogenase (LDH) levels is an indirect marker of tumor hypoxia, angioneogenesis
and worse prognosis. Lactic dehydrogenase (LDH), which is a glycolytic enzyme, composed of
four polypeptide chains, each one encoded by separate gene (M and H), exists in various types
of human tissue and neoplasms. LDH is a key enzyme in the conversion pyruvate to lactate
under anaerobic conditions .Five isoforms of LDH have been identified as a result of the five
different combinations of polypeptide subunits.
Hypoxia represents a clinical biological mechanism for treatment resistance in cancer cells
via the formation of new blood vessels. Furthermore, a growing body of evidence indicates
that hypoxia might actually promote cancer development.
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