Hepatocellular Carcinoma Clinical Trial
Official title:
Liver Perfusion MRI With Quantification of Tumoral Perfusion for Early Assessment of the Response of Antiangiogenics Treatments in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with an incidence of
500 000 cases per year. HCC most commonly appears in a context of liver chronic disease
(patient with chronic viral hepatitis (hepatitis B or hepatitis C) or with cirrhosis).
Surgical resection and liver transplantation concern patients with early stage and are the
only curative treatments. Transcatheter arterial chemoembolization, Radiation Therapy and
antiangiogenics treatments concern patients with inoperable lesions (palliative treatments).
Antiangiogenic treatments enable to inhibit the angiogenesis process and thus interrupt the
blood supply to the tumor. In clinical practice, the efficacy of anti-angiogenic agents is
usually assessed by methods based on morphological medical imaging. The measures of each
target lesion are obtained by Response Evaluation Criteria In Solid Tumor (RECIST) criteria
and WHO.
However, these morphological measures are not fully evaluated. An alternative to these is the
functional medical imaging which assess changes before that a diminution of tumor size is
detectable. Since these treatments induce generally necrosis without modification of initial
tumor size, the new technologies of functional medical imaging are particularly adapted to an
early evaluation of the response to treatments which may improve patient management.
In this context, liver Perfusion MRI needs to be assessed in its capacities to early predict
the response of antiangiogenic treatments.
Positive results will enable to adapt therapy in order to improve overall survival of
patients and avoid expensive treatments which may turn out to be inefficient and generating
important side-effects.
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