Hepatocellular Carcinoma Clinical Trial
Official title:
Comparison of Two Solvents Used With Chemotherapy Agent for Transarterial Chemoembolization of Hepatocellular Carcinoma
TACE is considered the standard treatment for unresectable HCC and is widely used as a palliative treatment. However there is no consensus of the protocol of TACE.One of the variation is does the stability of the suspension by emulsified the lipiodol and the contrast medium used to dissolve the anticancer agents really effect the survival.Thus the investigators conduct this prospective,randomized controlled study to find out if the different method of preparing chemotheraputic drugs can cause a different survival benefit.
Transcatheter arterial chemoembolization is currently the mainstays of palliative treatments
worldwide for patients with unresectable HCC. However there is no standard protocol exists
for TACE currently. One of the controversy is does the way of emulsified the anticancer
agents and lipiodol to get a high stability suspension really effect the survival rates.
Anticancer drugs play important role in survival benefit. Many studies have innovated
different methods to get a high stability suspension of lipiodol and anticancer drugs
,because they think lipiodol can selectively retained in HCC and used as a drug-carrying
which allow a slow release of the anticancer drug from lipiodol microdroplets. Thus ,A
stability suspension might get a maximize tumor drug uptake,which can caused a more tumor
necrosis, and minimize systemic drug levels ,which get a less toxicity, hence survival
benefit. While the other researcher think a stability emulsion can't get a positive effect
,such as pharmacokinetic and systematic toxicity of the anticancer drugs, tumor response,
biologic response and so on.
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