Hepatocellular Carcinoma Clinical Trial
Official title:
The Efficiency of Postoperative Interferon-alpha(IFNa) Treatment in p48 Positive Patients With Hepatocellular Carcinoma
The purpose of the study is to determine whether interferon-alpha is effective in the treatment of p48 Positive patients with HCC after curative resection.
BACKGROUND: Postoperative interferon-alpha (IFN-alpha) therapy improved survival in patients
with hepatocellular carcinoma (HCC). P48 is a predictive marker for outcome of postoperative
interferon-alpha treatment in patients with HCC. Our study is to identify the Efficiency of
Postoperative IFN-Alpha Treatment in p48 Positive Patients With HCC.
METHODS: An immunohistochemical study of P48 was performed on specimens that were collected
from patients who underwent a curative resection of HCC. These patient with p48 Positive
were randomized divided into a treatment group who received postoperative IFN-alpha therapy
and a comparison group who not received. Besides the side effect, the overall survival rate
and the disease-free survival rate will be observed.
Anticipated RESULTS: IFN alpha treatment improved the overall survival of p48 Positive
patients with HCC after curative resection, probably by postponing recurrence.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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