Hepatocellular Carcinoma Clinical Trial
Official title:
A Randomized Controlled Trial of Transarterial Ethanol Ablation (TEA) With Lipiodol-Ethanol Mixture (LEM) Versus Transcatheter Arterial Chemoembolisation (TACE) for Unresectable Hepatocellular Carcinoma
The current randomized controlled trial comparing LEM and TACE aims to evaluate the safety and efficacy of LEM as compared to TACE for treating patients with unresectable HCC.
The standard loco-regional treatment for unresectable hepatocellular carcinoma is
transarterial chemoembolization (TACE). However, The drawback of conventional
chemoembolization (TACE) for liver cancer is that it cannot effectively embolize portal
venules supplying the tumors, therefore chemoembolization is difficult to completely
eradicate the tumor. Usually multiple treatments are required and tumor recurrences are
common.
Transarterial Ethanol Ablation (LEM) can potentially provide a better treatment outcome with
fewer treatment sessions. Preliminary results from a clinical study showed that the
complication rate is reduced while survival rate may be improved. This study aims to compare
survival duration and response rate between the treatments TACE and LEM.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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