Impact of Hepatitis C Virus Therapy on Central Nervous System Outcomes

Status Completed

Clinical Trial Summary

This study observes the effects of newly developed direct-acting antiviral (DAA) treatments on the central nervous system (CNS) of individuals with chronic Hepatitis C (HCV). The goals of this study are to determine the CNS impact of curing chronic HCV disease with newly established DAA therapies and how HIV alters this relationship.

Clinical Trial Description

The specific aims of the study are as follows: Aim 1. Impact of HCV Cure on CNS Outcomes. Determine how curing HCV without IFN alters CNS outcomes in substance users with chronic HCV disease. Aim 2. Correlates of CNS Outcomes. Determine the viral and host correlates of Aim 1's neurocognitive outcomes. Aim 3. Impact of HIV Co-infection. Explore how HIV alters the relationships observed in Aims 1 and 2. Hypothesis 3: Compared with HCV mono-infected adults, SVR will be less likely to result in improved CNS outcomes in HCV/HIV co-infected adults. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02650024
Study type	Observational
Source	University of California, San Diego
Contact
Status	Completed
Phase
Start date	January 2016
Completion date	April 2021

View Details

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