Hepatitis C Clinical Trial
Official title:
Phase 1, Open Label Study to Evaluate the Effect of Omeprazole and Ritonavir on GSK2336805 Pharmacokinetics in Healthy Adults
This study is a Phase I open label drug interaction study to evaluate the effect of omeprazole and ritonavir on GSK2336805.
This study is a Phase I open label drug interaction study with two objectives. The first
objective of this study (Cohort 1) is to determine if the pharmacokinetics of a single dose
of GSK2336805 are affected by co-administration with repeat doses of omeprazole, a
proton-pump inhibitor that is commonly used by chronic hepatitis C patients .
The second objective of this study (Cohort 2) is to determine if the pharmacokinetics of a
single dose of GSK2336805 are affected by co-administration with repeat doses of ritonavir, a
HIV protease inhibitor drug that is a potent inhibitor of CYP 3A4.
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