HIV Infection Clinical Trial
Official title:
A Phase I Study to Evaluate the Safety and Immunogenicity of Simultaneous Prime-Boost Immunisations With Candidate HCV and HIV-1 Vaccines, AdCh3NSmut1 / ChAdV63.HIVconsv and MVA-NSmut / MVA.HIVconsv, in Healthy Volunteers
This study is aimed at assessing the safety of candidate Hepatitis C vaccines AdCh3NSmut/MVA-NSmut and HIV vaccines ChAdV63.HIVconsv/MVA.HIVconsv when administered separately or in combination to healthy volunteers. The study also aims to assess the cellular immune response generated by these vaccines when administered as mentioned above.
Hepatitis C and HIV are both widespread pathogens. By the end of 2010, there were 2.3 million
people in Europe living with HIV, over half of whom were coinfected with the Hepatitis C
virus (HCV). Although vaccination is the optimal method of preventing infection, it has
proved extremely difficult to develop an effective vaccine against HIV and HCV due to the
enormous variation in strains around the world. This is caused by the extraordinary ability
of the viruses to change their genetic material.
Researchers at the University of Oxford have developed novel candidate vaccines against HIV
('HIV.consv') and HCV ('NSmut'). These vaccines have been inserted into the carrier viruses
Chimpanzee Adenovirus (ChAd or AdCh) and modified vaccinia virus Ankara (MVA), both of which
have excellent safety records. The aim of this study is to test for the first time the
response of the immune system when vaccines to both HIV and HCV are given together.
During this study, 32 healthy adults aged 18 to 50 years will be recruited into one of three
groups to receive either two or four intramuscular injections over a period of two months.
All participants will be followed up for a further six months (12 visits in total).
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