Hemostasis Clinical Trial
Verified date | September 2007 |
Source | Kantonsspital Graubünden |
Contact | n/a |
Is FDA regulated | No |
Health authority | Switzerland: Swissmedic |
Study type | Interventional |
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Status | Completed |
Enrollment | 11 |
Est. completion date | August 2007 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Healthy volunteers Exclusion Criteria: - Administration of drugs affecting platelets - History of bleeding - Gastrointestinal disorders - Hypersensitivity to aspirin and/or NSAID - Pregnancy and breast feeding |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Switzerland | Kantonsspital Graubünden, Department of Internal Medicine | Chur |
Lead Sponsor | Collaborator |
---|---|
Kantonsspital Graubünden |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | platelet aggregation | 5 days |
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