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Hemorrhage clinical trials

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NCT ID: NCT02885545 Withdrawn - Clinical trials for Chronic Kidney Disease

The Strategy to Prevent Hemorrhage Associated With Anticoagulation in Renal Disease Management (STOP HARM) Trial

STOP-HARM
Start date: September 2016
Phase: Phase 4
Study type: Interventional

Patients with severe chronic kidney disease (CKD) who develop atrial fibrillation are at high risk for stroke. The use of blood thinking medication in dialysis patients is controversial and warfarin carries a serious risk for major bleeding. The Watchman device may be an ideal therapy for this population as after implantation it allows for the discontinuation of blood thinners, thereby reducing the risk of bleeding.

NCT ID: NCT02851940 Withdrawn - Pain Clinical Trials

Pain and Bleeding Following Hypertonic Saline Sclerotherapy Compared to Brand Ligation for Symptomatic Hemorrhoids

Start date: September 2016
Phase: N/A
Study type: Interventional

The investigators aim at prospectively comparing procedural pain, adverse events and rebleeding rates of anoscopic rubber band ligation and endoscopic hypertonic saline injection in patients with symptomatic hemorrhoidal disease

NCT ID: NCT02807441 Withdrawn - Thrombosis Clinical Trials

Perioperative Bleeding and Aspirin Use in Spine Surgery

ASA
Start date: July 2016
Phase: Phase 3
Study type: Interventional

The investigators would like to further the current understanding of aspirin and its effects on perioperative bleeding by conducting a randomized controlled trial of spinal surgery patients receiving varying doses of aspirin or no aspirin perioperatively. The investigators hypothesize that there will be no significant difference in perioperative blood loss between the different groups.

NCT ID: NCT02798107 Withdrawn - Hemorrhage Clinical Trials

Observational Study to Evaluate Safety of Idarucizumab in Pediatric Patients

Start date: May 20, 2019
Phase:
Study type: Observational

Idarucizumab is a humanized monoclonal antibody fragment (Fab) that binds to dabigatran with very high affinity. Idarucizumab potently and specifically binds to dabigatran and its metabolites and neutralises its anticoagulant effect. A clinical development program is ongoing to support marketing authorisation submissions for idarucizumab indicated in patients treated with dabigatran who require emergency surgery/urgent procedures or who have a life-threatening or uncontrolledbleeding when rapid reversal of the anticoagulant effects of dabigatran is required.

NCT ID: NCT02724150 Withdrawn - Clinical trials for Peptic Ulcer Hemorrhage

Comparison of Low Against High Regimen of Proton Pump Inhibitors for Treatment of Acute Peptic Ulcer Bleeding

Start date: December 1, 2017
Phase: Phase 4
Study type: Interventional

Evaluate the efficacy of Two different regimens of proton pump inhibitors High against Low in the management of acute peptic ulcer bleeding

NCT ID: NCT02694341 Withdrawn - Bleeding Clinical Trials

Bakri Balloon in Placenta Previa

BB-ATS
Start date: December 2018
Phase: N/A
Study type: Interventional

The Bakri intrauterine balloon can achieve haemostasis in cases of postpartum haemorrhage, including haemorrhage associated with placenta previa by compressing the lower uterine segment.

NCT ID: NCT02677818 Withdrawn - Ischemic Stroke Clinical Trials

The Relationship Between Clotting Factor VIII and Bleeding Adverse Reactions in Patients Under the Therapies of Thrombolysis, Anticoagulation and Anti-platelet

Start date: May 2016
Phase:
Study type: Observational

The purpose of this study is to determine whether Plasma Factor VIII Levels are related to the treatment of bleeding in ischemic stroke(IS).

NCT ID: NCT02639819 Withdrawn - Clinical trials for Intracerebral Hemorrhage

Management of Intracerebral Hemorrhage With Aminocaproic Acid - Pilot Study

MANICHAN-PILOT
Start date: June 2016
Phase: Phase 1
Study type: Interventional

This is single-arm, open-label, safety and feasibility pilot study of ɛ-aminocaproic acid in ICH patients. Consecutive ICH volume with hematoma volume less than 30 mL by ABC/2 method presenting within 3 hours of symptom onset, meeting all inclusion criteria, and without exclusions will be consented and enrolled. Subjects will receive 5 grams of intravenous ɛ-aminocaproic acid over 1 hour, followed by the same at 1 mg/hour for 23 hours. Comupted tomography (CT) head will be done at 24 hours in order to follow hematoma size. Electrocardiogram, lower extremity venous Doppler and NIHSS will also be done at 24 hours. The patient will be followed in the clinic 30-90 days post discharge for functional status.

NCT ID: NCT02544256 Withdrawn - Clinical trials for Subarachnoid Hemorrhage, Aneurysmal

Mild Hypothermia During Intracranial Aneurysm Clipping

Start date: December 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether mild hypothermia causes reduction of vasoconstriction in microcirculation after clipping of aneurysms, and affects the blood flow in small diameter arteries at operating site (ischemia-hyperemia) and occurrence of vasospasms during the period of 14 postoperative days measured by transcranial Doppler.

NCT ID: NCT02528708 Withdrawn - Clinical trials for Postpartum Hemorrhage

A Program to Evaluate Riastap® and FIBTEM® for the Early Control and Treatment of Postpartum Hemorrhage (PERFECT PPH)

PERFECT PPH
Start date: January 2021
Phase: Phase 1/Phase 2
Study type: Interventional

In this prospective, single-center, randomized, placebo-controlled, double-blind clinical trial, parturients with primary PPH are eligible for treatment with fibrinogen concentrate following both vaginal delivery and cesarean section complicated by an estimated blood loss (EBL) >1000 mL and an ongoing bleeding notwithstanding standard treatment measures (volume replacement, uterine massage, and uterotonic agents).