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Hematopoiesis clinical trials

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NCT ID: NCT04853511 Recruiting - Inflammation Clinical Trials

Comprehensive Assessment of Interconnection Between Brain Emotional Activity and Coronary Plaque Instability

Start date: February 14, 2022
Phase:
Study type: Observational [Patient Registry]

Emotional stress is associated with future cardiovascular events. However, the biological interconnection between brain emotional neural activity and acute plaque instability is not fully understood. Optical coherence tomography-Fluorescence Lifetime (OCT-FLIM) dual modal intravascular imaging is a novel technique that enables comprehensive assessment of structural and biochemical characteristics of coronary atheroma and estimates the level of plaque instability. 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) enables simultaneous estimation of multi-system activities including emotional stress, arterial inflammation, and hematopoiesis. The present study aims to prospectively investigate mechanistic linkage between coronary plaque instability, stress-associated neurobiological activity, and macrophage hematopoiesis using OCT-FLIM and 18F-FDG PET/CT imaging assessment.

NCT ID: NCT04711746 Recruiting - Pulmonary Embolism Clinical Trials

Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

HEMEP
Start date: February 1, 2021
Phase: N/A
Study type: Interventional

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

NCT ID: NCT02964286 Recruiting - Cancer, Breast Clinical Trials

The Effect of Acupoint Massotherapy on Relieving Chemotherapy-induced Myelosupression

Start date: July 2015
Phase: N/A
Study type: Interventional

In this proposed project, the investigator will estimate the effect of massotherapy of acupoints on alleviating chemotherapy-induced myelosuppression among patients with cancer.

NCT ID: NCT01094197 Withdrawn - Wounds and Injuries Clinical Trials

Detailed Evaluation of Microchimerism

Start date: March 2010
Phase: N/A
Study type: Observational

Individuals who experience traumatic injury often require blood transfusion. In some individuals who receive blood after an injury, white blood cells from a person who donated blood may remain in the body for years, a condition known as microchimerism. This study is designed to examine a group of people who are known to have long-term microchimerism and, through analysis of their blood, determine whether there is evidence that the microchimerism involves blood stem cells that can become any type of blood cell (red blood cells, white blood cells, or platelets) and that might be a permanent part of the body.