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Hemangioma, Capillary clinical trials

View clinical trials related to Hemangioma, Capillary.

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NCT ID: NCT06273111 Not yet recruiting - Hemangioma Skin Clinical Trials

Topical Simvastatin for Treating Infantile Hemangioma

TSTIH
Start date: April 1, 2024
Phase: Early Phase 1
Study type: Interventional

This is a 24-week, open-label pilot study to evaluate the safety and preliminary efficacy of 5% simvastatin ointment in treating 12 children with superficial IH. The primary objective: To evaluate the safety and tolerability of topical treatment with 5% simvastatin ointment for superficial IH over 24 weeks. The secondary objective: 1.1 To evaluate the efficacy of 5% simvastatin ointment when topical treatment is administered twice daily for 24 weeks. Evaluation is performed at each clinic visit via investigator global assessment (IGA) based on standardized 3D digital photography and hemangioma activity score (HAS). 1.2 To evaluate the impact of 5% simvastatin ointment on quality of life using the IH-QoL questionnaire.

NCT ID: NCT06080724 Completed - Clinical trials for Comparison of Efficacy of Sclerotherapy in Infantile Hemangioma

Efficacy of Intralesional Bleomycin Alone and in Combination With Dexamethasone in Infantile Haemangiomas

hemangioma
Start date: March 22, 2021
Phase: N/A
Study type: Interventional

Objective: This study is intended to compare the outcome of intralesional bleomycin with dexamethasone versus the bleomycin alone in infantile haemangioma. Materials and Methods: This RCT was performed after the ethical approval at the pediatric surgery department of KEMU/Mayo hospital Lahore. 114 patients were enrolled in two groups A and B. Both groups contained 57 patients each. Group A was administered intralesional bleomycin with dexamethasone and group B was given intralesional bleomycin alone with a space of 4 weeks. Selection of patients was made according to inclusions and exclusion criteria.

NCT ID: NCT05841628 Recruiting - Port-Wine Stain Clinical Trials

Tolerability of 532 nm Laser Treatment of Port Wine Stains

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

The goal of this study is to learn about treatment of port wine birthmarks treated with an FDA-approved 532 nm laser. The main questions it aims to answer are: - How well are the treatments tolerated? - Are there differences in tolerability of the treatment when a single high fluence laser pulse is used (the standard treatment) versus using multiple low fluence pulses? - Are there differences in results when using a single high fluence pulse versus multiple low fluence pulses? type of study: Clinical Trial Participants will undergo 3 monthly laser treatments with the 532 nm DermaV laser. Part of their birthmark will be treated with the standard single-pulse high fluence approach, and other parts will be treated with the multiple-pulse low fluence approach.

NCT ID: NCT05771311 Recruiting - Port-Wine Stain Clinical Trials

KTP Laser vs Pulsed Dye Laser for Port-Wine Stains

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

To compare the efficacy and safety of 532nm KTP laser and 585 nm pulsed dye laser for treating port-wine stains.

NCT ID: NCT05479123 Recruiting - Clinical trials for Infantile Hemangioma

Assessing the Impact of Dosage Frequency of Propranolol on Sleep Patterns in Patients With Infantile Hemangiomas

Start date: June 23, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the baseline sleep pattern disruption for patients starting oral propranolol at the standard BID dosing regimen compared to the control (timolol) group and to determine if there is a significant improvement in the sleep patterns in infants taking oral propranolol on the TID dosing regimen versus the control (timolol) group

NCT ID: NCT05187923 Recruiting - Clinical trials for Infantile Hemangiomas

Computer Aided Tool for Diagnosis of Neck Masses in Children

Start date: January 1, 2021
Phase:
Study type: Observational

The aim of this study was to evaluate the diagnostic efficacy of computer aided diagnostic tool for neck masses using machine learning and deep learning techniques on clinical information and radiological images in children.

NCT ID: NCT05171894 Not yet recruiting - Port-Wine Stain Clinical Trials

A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin + PDT

Start date: August 31, 2023
Phase: Phase 2
Study type: Interventional

This is a multi-center, randomized, double-blind, vehicle-controlled, and sequential group Phase 2 study. Eligible subjects aged 18 to 65 years old with PWB of face and/or neck area (except subjects for Stage One) will receive Hemoporfin PDT or vehicle PDT in 8-week cycles at fixed drug dose (5 mg/kg) and different light fluence.

NCT ID: NCT05080868 Completed - Clinical trials for Hemangioma, Capillary

Infantile Hemangioma With Minimal or Arrested Growth : Epidemiology, Clinical Characteristics and Evolution

Start date: March 23, 2021
Phase:
Study type: Observational

Infantile hemangioma (IH) is the most common vascular tumor of infancy, characterized by its clinical history. Absent at birth or present under the form of a premonitory mark, they display a rapid proliferative phase starting in the first weeks of life. Then, after a plateau phase, they slowly involute. However, a subtype of IH named "abortive", "minimal or arrested growth", "reticular" or "telangiectatic" hemangioma differs from typical IH because it doesn't have a proliferative component, or only a minimal one. This subtype of hemangioma has been recently described and data are lacking regarding its proportion among infantile hemangioma and its differences with "classic" infantile hemangioma. The aim of this study is to estimate the proportion of abortive hemangioma among infantile hemangioma. Also, the investigators aim to compare the clinical characteristics of "classic" infantile hemangiomas and abortive hemangiomas. Lastly, investigators wished to study the evolution of abortive hemangioma.

NCT ID: NCT04999618 Completed - Vascular Diseases Clinical Trials

A New Approach in Laser Surgery Using the Regenerative Solution in Children Diagnosed With Vascular Pathology

DOUBLE-SKIN
Start date: January 1, 2020
Phase: Phase 4
Study type: Interventional

Laser treatment (LT) is the first-line treatment for Vascular Pathology. However even when LT is based on the selective photothermolysis it causes the first-degree burns. While being typically benign by affecting only the epidermis, or outer layer of skin, the burn site is remaining red, dry, and very painful. As Haemoblock contains nanoparticles of silver and is known for both bactericidal and bacteriostatic effects, it likely decreases the potential for infection postoperatively. Furthermore, after fibrin replaces the superficial structure "Hemoblock-albumin", the polyacrylate matrix is plasmolyzed which initiates the cascade of signals required for the tissue regeneration processes. Objective of the study was to examine the effect of the Regenerative Solution "Hemoblock" in lowering postoperative complications in children diagnosed with Vascular Pathology undergoing a laser surgery if delivered with transdermal patches.

NCT ID: NCT04684667 Not yet recruiting - Clinical trials for Infantile Hemangioma

''Efficacy of Propranolol in the Treatment of Infantile Hemangioma"

Start date: January 1, 2021
Phase: Phase 2
Study type: Interventional

''Evaluation of the Efficacy of Propranolol in the Treatment of Infantile Hemangioma"