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Hemangioma, Capillary clinical trials

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NCT ID: NCT06273111 Not yet recruiting - Hemangioma Skin Clinical Trials

Topical Simvastatin for Treating Infantile Hemangioma

TSTIH
Start date: April 1, 2024
Phase: Early Phase 1
Study type: Interventional

This is a 24-week, open-label pilot study to evaluate the safety and preliminary efficacy of 5% simvastatin ointment in treating 12 children with superficial IH. The primary objective: To evaluate the safety and tolerability of topical treatment with 5% simvastatin ointment for superficial IH over 24 weeks. The secondary objective: 1.1 To evaluate the efficacy of 5% simvastatin ointment when topical treatment is administered twice daily for 24 weeks. Evaluation is performed at each clinic visit via investigator global assessment (IGA) based on standardized 3D digital photography and hemangioma activity score (HAS). 1.2 To evaluate the impact of 5% simvastatin ointment on quality of life using the IH-QoL questionnaire.

NCT ID: NCT05171894 Not yet recruiting - Port-Wine Stain Clinical Trials

A Study to Evaluate Efficacy and Safety of Light Dose in Subjects With PWB Treated With Hemoporfin + PDT

Start date: August 31, 2023
Phase: Phase 2
Study type: Interventional

This is a multi-center, randomized, double-blind, vehicle-controlled, and sequential group Phase 2 study. Eligible subjects aged 18 to 65 years old with PWB of face and/or neck area (except subjects for Stage One) will receive Hemoporfin PDT or vehicle PDT in 8-week cycles at fixed drug dose (5 mg/kg) and different light fluence.

NCT ID: NCT04684667 Not yet recruiting - Clinical trials for Infantile Hemangioma

''Efficacy of Propranolol in the Treatment of Infantile Hemangioma"

Start date: January 1, 2021
Phase: Phase 2
Study type: Interventional

''Evaluation of the Efficacy of Propranolol in the Treatment of Infantile Hemangioma"

NCT ID: NCT04536740 Not yet recruiting - Port-Wine Stain Clinical Trials

Effect of Pulsed Dye Laser on Photodynamic Therapy of Port-Wine Stains

Start date: October 1, 2020
Phase: N/A
Study type: Interventional

Port-wine stain (PWS) is a congenital capillary malformation with an incidence of 3-5/1000 newborns and grows commensurately with the affected individual. Although PDL treatment can significantly lighten and reduce most PWS lesions, 20% of cases show little improvement after treatment. Our previous researches suggested that PDT may be a beneficial option for PWS cases that are resistant to multiple PDL treatments. In this study, a single center, prospective, parallelled, controlled study was conducted to compare the efficacy of PDT on PWS treated with standard PDL and those without any treatment.