Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Reduction in the peak deep body temperature |
Rectal temperature measurement during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Reduction in the resting deep body temperature |
Rectal temperature measurement during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Reduction in the peak mean body temperature |
Weighted rectal and mean skin temperature measurement during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Reduction in the resting mean body temperature |
Weighted rectal and mean skin temperature measurement during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Increased plasma volume |
Change in plasma volume calculated from resting haemoglobin and haematocrit prior to a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Increased sweating rate |
Sweating rate calculated from change in nude body mass and accounting for fluid consumption during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Reduced sweat sodium concentration |
Sweating sodium concentration assessed from sweat collected in a custom sweat patch on the back during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Reduced exercise heart rate |
Heart rate measured using chest telemetry during a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Increased resting intracellular heat shock protein 70 content |
Assessed in peripheral blood mononuclear cells obtained before a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Increased post heat stress intracellular heat shock protein 70 content |
Assessed in peripheral blood mononuclear cells obtained after a heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Increased resting intracellular heat shock protein 90 alpha content |
Assessed in peripheral blood mononuclear cells obtained before a heat stress tests |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Increased post heat stress intracellular heat shock protein 90 alpha content |
Assessed in peripheral blood mononuclear cells obtained after a heat stress tests |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Maximal oxygen uptake |
Highest rate of oxygen uptake during graded cycling exercise |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Lactate threshold |
Power output at 4 mmol.L-1 blood lactate during graded cycling exercise |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Gross mechanical efficiency |
Percentage ratio of external work achieved compared to the total energy expenditure during graded cycling exercise below the lactate threshold |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Peak power output |
Highest power output achieved during exhaustive cycling exercise |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Peripheral oxygen saturation during exposure to hypoxia |
Assessed using ear or finger tip pulse oximetry during a hypoxic tolerance test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Heart rate during exposure to hypoxia |
Assessed using chest telemetry during a hypoxic tolerance test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Minute ventilation during exposure to hypoxia |
Expire volume of air per minute during a hypoxic tolerance test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Plasma neutrophil gelatinase-associated lipocalin |
Concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Urine neutrophil gelatinase-associated lipocalin |
Concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Plasma kidney injury molecule-1 |
Concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Urine kidney injury molecule-1 |
Concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Tissue inhibitor of metalloproteinase 2 |
Urine concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Insulin-like growth factor-binding protein 7 |
Urine concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Intestinal fatty acid binding protein |
Serum concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Soluble cluster of differentiation 14 |
Plasma concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Lipopolysaccharide binding protein |
Plasma concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Interleukin-6 |
Plasma concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|
Secondary |
Cortisol |
Plasma concentration change pre to post heat stress test |
Pre heat acclimation intervention (up to 1 week) to post heat acclimation intervention (up to 1 week) |
|