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Gender-based Differences in the Outcome of Treatment With Aldosterone Antagonists in Patients With Heart Failure — GBDAL-HF  

Heart Failure Clinical Trial

Official title:
The Gender-Based Differences in the Outcome of Treatment by Aldosterone Antagonists in Patients With Heart Failure

Clinical Trial Summary

Heart failure (HF) is a major healthcare problem. In patients with Heart Failure with Reduced Ejection Fraction (HFrEF), aldosterone antagonists reduce mortality and hospitalization rate. Gender-related differences have been described in the regulation of renin angiotensin aldosterone system (RAAS), which is at the core of the pathophysiology of HF. Regarding gender-related differences in the use of MRAs, less is known about the effects of androgens on RAAS. In this single-center prospective cohort, a total of 100 adult (≥ 18 years) ambulatory patients of both sexes with the diagnosis of HF with HFrEF (LVEF≤ 40%) and NYHA class II-IV under optimized medical therapy started an aldosterone antagonist are enrolled and followed-up for 6 months. Patients are categorized according to their apparent sexual gender into two groups: the male group and the female group.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06233695
Study type Observational
Source Alexandria University
Contact
Status Completed
Phase
Start date October 15, 2022
Completion date December 1, 2023
View Details
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