Heart Failure Clinical Trial
Official title:
An Exploratory Clinical Study of JV001 in the Treatment of Patients With Heart Failure Due to Dilated Cardiomyopathy (Telomere Recapping to Restore Mitochondrial Biogenesis Study for Dilated Cardiomyopathy)
The aim of this study is to determine the safety and feasibility of giving an adeno-associated viral vector expressing a modified telomerase protein (TERT), driven by cardiac troponin T promoter (AAV9-cTnT-modTERT), to 15 dilated cardiomyopathic patients.
It is an open-label, 3+3 design dose escalation study involving three dosages (of 2×10^11vg/kg，6×10^11vg/kg，and 2×10^12vg/kg) aimed to explore the safety, pharmacokinetics, immunology and preliminary efficacy of JV001. ;
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