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Clinical Trial Summary

This study is a prospective monocentric, randomized, double-blind, placebo-controlled, crossover clinical trial to assess the efficacy of Sacubitril/Valsartan over placebo in improving exercise capacity and neurohormonal activation in adults with moderate to severe systemic RV dysfunction and NYHA class II or III symptoms.

Clinical Trial Description

Subjects who qualify will be approached and those consenting will be enrolled to undergo a baseline evaluation. An active run-in-phase of 6 weeks will identify each patient's maximal tolerated dose of Sacubitril/Valsartan. Then, each treatment arm (Sacubitril/Valsartan and placebo) will be 24 weeks duration prior to crossover. At the end of each study arm (24 weeks), data regarding primary and secondary endpoints will be collected. The total duration of the study for the patient will be 15 months. Subjects will undergo regular visits (in-clinic, and/or by phone, or video conferencing) half-way and at the end of each arms. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05117736
Study type Interventional
Source Montreal Heart Institute
Contact Veronique Roy, Nurse
Phone 0015143763330
Email [email protected]
Status Not yet recruiting
Phase N/A
Start date November 15, 2021
Completion date November 12, 2024

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