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A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data

Heart Failure Clinical Trial

Official title:
A Cohort Study to Compare the Hospitalization Between Naive Sacubitril/Valsartan and Naive ACEi/ARBs Heart Failure Patients With Reduced Ejection Fraction Using Secondary US Electronic Health Records Data

Clinical Trial Summary

A non-interventional retrospective cohort study conducted to compare the naive sacubitril/valsartan Heart Failure with reduced Ejection Fraction (HFrEF) patient population to a matched naive ACEi/ARB HFrEF patient population.

Clinical Trial Description

This was a non-interventional retrospective cohort study using the US secondary EHR dataset, Optum EHR, to compare the naive sacubitril/valsartan HFrEF patient population (aged ≥ 18 years) to a matched naive ACEi/ARB HFrEF patient population. The study comprised of the following periods: Identification period: 01-Jul-2015 to 31-Mar-2019 Study period - 01-Jul-2014 to 31-Mar-2020 for primary objective and secondary objective 2 to 6. - 01-Jul-2008 to 30-Sep-2020 for secondary objective 1. Follow-up period: Patients were followed up until 31-Mar-2020, death or patient transfer out. Baseline period: 365 days prior to index ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05096143
Study type Observational
Source Novartis
Contact
Status Completed
Phase
Start date June 3, 2020
Completion date October 19, 2020
View Details
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