Heart Failure Clinical Trial
Official title:
To Explore the Potential of UCH-L1 as a Novel Therapeutic and Diagnostic Target in Heart Failure
Autophagy is considered an important component of Heart failure progression. Deubiquitination enzymes play an important role in autophagy. An important regulatory process within the autophagy pathway is ubiquitination. Ubiquitination targets proteins for degradation. On the contrary, de-ubiquitinating proteins (such as UCHL1) reverses this process. Studies have demonstrated deubiquitination to be linked to certain pathological processes, such as heart failure. UCHL1 will be examined as a potential marker of disease progression in acute decompensated heart failure.
Status | Recruiting |
Enrollment | 90 |
Est. completion date | April 1, 2025 |
Est. primary completion date | January 1, 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - Admission for decompensated HF (traditional diagnostic criteria will be utilized for diagnosing ADHF - presence of dyspnea as presenting complaint; evidence of volume overload - peripheral or pulmonary edema, elevated jugular venous pressure > 10 cmH2O, presence of hepatojugular reflux, or ascites; elevated B-type Natriuretic Peptide (>100ng/ml); evidence of pulmonary vascular congestion on chest x-ray1, or Admission for dyspnea that is NOT related to ADHF (absence of all HF symptoms and signs mentioned in ADHF inclusion criteria- except for dyspnea as presenting complaint) - Able to give informed consent - Age >= 18 years Exclusion Criteria: - Mortality during inpatient observation - Presence of acute stroke (ischemic or hemorrhagic) - Presence of intracranial hemorrhage - History of acute stroke (ischemic or hemorrhagic) or intracranial hemorrhage within the preceding 6 months - Presence of decompensated liver disease (elevated ALT/AST; ascites; Acute variceal bleeding; or hepatic encephalopathy) - Presence of sepsis - Presence of severe hyponatremia (Serum sodium < 130 meq/L) - Active malignancy (undergoing chemotherapy, radiation therapy, or planned surgical intervention) - SARS-CoV-2 positive during the current admission |
Country | Name | City | State |
---|---|---|---|
United States | Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC | Columbia | South Carolina |
Lead Sponsor | Collaborator |
---|---|
VA Office of Research and Development | William Jennings Bryan Dorn VA Medical Center |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Diagnostic accuracy | Assess accuracy of UCHL1 to diagnose ADHF as well as correlate with improvement | 30 days |
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