Heart Failure Clinical Trial
Official title:
Comparison of the Acute Hemodynamic Effect of Three Modes of Stimulation in Cardiac Resynchronization.
Cardiac Resynchronization Therapy (CRT) is an established treatment for patients with
systolic heart failure and bundle branch block, improving functional capacity, quality of
life and reducing morbi-mortality.
Adjusting atrio-ventricular (AV) delay, vector optimization and choice of different modes of
stimulation can influence the acute hemodynamical consequences of CRT but also its
medium-term and long-term clinical and echocardiographic effects.
The aim of the present prospective study is to investigate whether the different stimulation
modes lead to different acute hemodynamic response, by evaluating the highest systolic
pressure using the Finapress ® method.
This study is a non-randomized, prospective, interventional, multicentric study.
Patients implanted with an Abbott ® CRT pacemaker or defibrillator since less than 3 months
are eligible for the study.
Recruited patients will be submitted to a non-invasive evaluation of different pacing modes.
This will be performed using the Finapress NOVA device, which records blood pressure with a
digital cuff. The peak of blood pressure will correspond to the optimal device settings
Three modes of stimulation of ABBOTT CRT devices will be compared:
- Classical bi-ventricular pacing mode at nominal value and with AV delay optimization
- SyncAV mode at nominal value or with left ventricular preexcitation optimization
- Multipoint Pacing (MPP) mode, alone or in combination with SyncAV mode This is an acute
evaluation study without scheduled follow-up.
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