Heart Failure Clinical Trial
Official title:
A Randomised Cross-over Pilot Study of the Effect of His-Ventricular (HV) Interval Optimisation in Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) is a specialised type of pacemaker used in patients
with severe heart failure to improve symptoms and survival. Approximately one third of
patients treated with CRT do not notice significant improvement in their symptoms and this
may be due to inadequate co-ordination between the upper and lower chambers of the heart
(atrioventricular dyssynchrony).
The investigators propose a new method to achieve atrioventricular synchrony in CRT based on
measurements of electrical conduction from within the heart. Patients referred for CRT
implantation at Castle Hill Hospital are eligible to participate. During CRT implantation,
additional measurements, will be recorded from within the heart. After implantation, device
settings will be adjusted to either standard or electrophysiologically-optimised settings
with cross-over at 4 months.
The investigators hypothesis is that patients with optimised settings will derive additional
benefit compared to patients with standard pacemaker-determined settings.
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