Supportive Treatment of Severe Heart Failure by Renal Denervation — Heart-RND  

Heart Failure Clinical Trial

Official title: Supportive Treatment of Severe Heart Failure by Renal Denervation

Status Terminated

Clinical Trial Summary

The overactivity of sympathetic nervous system is worsening the hemodynamic state of heart failure patients. The present study is planned to reduce the sympathetic tone in patients with severe heart failure by renal nervous denervation.

Clinical Trial Description

The patient population consists of heart failure patients who are not responding properly to medication and biventricular pacing therapy. The inappropriate response to these therapies is evaluated by patient history (NYHA III-IV), echocardiography (EF < 45%), 6-minute walking test (<440m) and measurements of P-ProBNP. The patients who fulfill the inclusion criteria will undergo renal nervous denervation. The patients will be followed up with the same methods as they were recruited to the study (by patient history (NYHA III-IV), echocardiography (EF < 45%), 6-minute walking test (<440m) and measurements of P-ProBNP). The overall time of follow-up will be 24 months. The patients are randomised according to the waiting list principle in a manner to 1:1. The waiting time will be 6 months. ;

Related Conditions & MeSH terms

• Heart Failure

• NCT number: NCT02638324
• Study type: Interventional
• Source: Turku University Hospital
• Status: Terminated
• Phase: N/A
• Start date: December 1, 2014
• Completion date: January 30, 2019