Heart Failure Clinical Trial
Official title:
Intracardiac Haemo-dynamics and Echocardiographic Assessment to Optimise Lead Placement for CRT
Cardiac resynchronisation therapy (CRT) using biventricular pacing (BiVP) is established as
an effective treatment for heart failure. Unfortunately up to 45% of patients do not
respond, with no improvement in symptoms or cardiac size. Reducing the proportion of
non-responders has become the key research focus in CRT.
Targeting the position of the left ventricular (LV) pacing lead within the coronary vein
network has previously been shown to increase the proportion of responders to CRT. Several
techniques have been tried for targeting lead position, of which the best investigated are
the use of speckle-tracking echocardiography to target the lead position to the site of
latest mechanical activation of the left ventricle, and the use of invasive monitoring to
select the pacing site at which the greatest acute haemodynamic response (AHR) to BiVP
occurs. Both techniques are limited by groups of patients in whom the techniques are not
possible or provide limited useful information.
The relationship between these two measures is unknown - there are no previous studies that
have investigated correlation between the site of latest mechanical activation determined by
echo and the site of maximal AHR. It is likely that a hybrid technique using both of these
investigations might allow optimal lead positioning in more patients, or that if the
information is shown to be equivalent, more streamlined techniques can be designed.
This study will also be able to contribute towards several important secondary questions. In
particular the investigators will study the possibility of using non-invasive cardiac output
monitoring (NICOM) to assess haemodynamic response rather than an intravascular pressure
monitor wire. The investigators also wish to assess whether the site of latest mechanical
activation is changed by right ventricular pacing.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05654272 -
Development of CIRC Technologies
|
||
| Recruiting |
NCT05650307 -
CV Imaging of Metabolic Interventions
|
||
| Recruiting |
NCT05196659 -
Collaborative Quality Improvement (C-QIP) Study
|
N/A | |
| Active, not recruiting |
NCT05896904 -
Clinical Comparison of Patients With Transthyretin Cardiac Amyloidosis and Patients With Heart Failure With Reduced Ejection Fraction
|
N/A | |
| Completed |
NCT05077293 -
Building Electronic Tools To Enhance and Reinforce Cardiovascular Recommendations - Heart Failure
|
||
| Recruiting |
NCT05631275 -
The Role of Bioimpedance Analysis in Patients With Chronic Heart Failure and Systolic Ventricular Dysfunction
|
||
| Enrolling by invitation |
NCT05564572 -
Randomized Implementation of Routine Patient-Reported Health Status Assessment Among Heart Failure Patients in Stanford Cardiology
|
N/A | |
| Enrolling by invitation |
NCT05009706 -
Self-care in Older Frail Persons With Heart Failure Intervention
|
N/A | |
| Recruiting |
NCT04177199 -
What is the Workload Burden Associated With Using the Triage HF+ Care Pathway?
|
||
| Terminated |
NCT03615469 -
Building Strength Through Rehabilitation for Heart Failure Patients (BISTRO-STUDY)
|
N/A | |
| Recruiting |
NCT06340048 -
Epicardial Injection of hiPSC-CMs to Treat Severe Chronic Ischemic Heart Failure
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05679713 -
Next-generation, Integrative, and Personalized Risk Assessment to Prevent Recurrent Heart Failure Events: the ORACLE Study
|
||
| Completed |
NCT04254328 -
The Effectiveness of Nintendo Wii Fit and Inspiratory Muscle Training in Older Patients With Heart Failure
|
N/A | |
| Completed |
NCT03549169 -
Decision Making for the Management the Symptoms in Adults of Heart Failure
|
N/A | |
| Recruiting |
NCT05572814 -
Transform: Teaching, Technology, and Teams
|
N/A | |
| Enrolling by invitation |
NCT05538611 -
Effect Evaluation of Chain Quality Control Management on Patients With Heart Failure
|
||
| Recruiting |
NCT04262830 -
Cancer Therapy Effects on the Heart
|
||
| Completed |
NCT06026683 -
Conduction System Stimulation to Avoid Left Ventricle Dysfunction
|
N/A | |
| Withdrawn |
NCT03091998 -
Subcu Administration of CD-NP in Heart Failure Patients With Left Ventricular Assist Device Support
|
Phase 1 | |
| Recruiting |
NCT05564689 -
Absolute Coronary Flow in Patients With Heart Failure With Reduced Ejection Fraction and Left Bundle Branch Block With Cardiac Resynchronization Therapy
|