Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Heart Failure Clinical Trial

— RER-CRT  

Official title:

Study of Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01924221
• Other study ID #: NA_00065477
• Status: Completed
• Start date: December 2011
• Est. completion date: August 1, 2022

Study information

• Verified date: August 2022
• Source: Johns Hopkins University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 31
• Est. completion date: August 1, 2022
• Est. primary completion date: August 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 100 Years

Eligibility

Inclusion Criteria:

• patients undergoing implantation of a CRT-D

Exclusion Criteria:

• age < 18 y

• pregnancy or planned pregnancy

Related Conditions & MeSH terms

• Atrial Remodeling
• Heart Failure
• Patients Undergoing CRT-D Device Implantation

Locations

Country	Name	City	State
United States	Johns Hopkins Hospital	Baltimore	Maryland

Sponsors (1)

Lead Sponsor	Collaborator
Johns Hopkins University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	correlation between electrical and mechanical remodeling	correlation between electrical and mechanical measures of dyssynchrony	6 months after CRT implantation